Preclinical evaluation of NF-κB-triggered dendritic cells expressing the
viral oncogenic driver of Merkel cell carcinoma for therapeutic
vaccination

Preclinical evaluation of NF-κB-triggered dendritic cells expressing the viral oncogenic driver of Merkel cell carcinoma for therapeutic vaccination

Background: Merkel cell carcinoma (MCC) is a rare but very aggressive skin tumor that develops after integration of a truncated form of the large T-antigen (truncLT) of the Merkel cell polyomavirus (MCV) into the host’s genome. Therapeutic vaccination with dendritic cells (DCs) loaded with tumor ant...

Full description

Bibliographic Details
Main Authors:	Kerstin F. Gerer, Michael Erdmann, Sine R. Hadrup, Rikke Lyngaa, Lena-Marie Martin, Reinhard E. Voll, Beatrice Schuler-Thurner, Gerold Schuler, Niels Schaft, Stefanie Hoyer, Jan Dörrie
Format:	Article
Language:	English
Published:	SAGE Publishing 2017-07-01
Series:	Therapeutic Advances in Medical Oncology
Online Access:	https://doi.org/10.1177/1758834017712630

Similar Items

BRAF and MEK Inhibitors Influence the Function of Reprogrammed T Cells: Consequences for Adoptive T-Cell Therapy
by: Jan Dörrie, et al.
Published: (2018-01-01)

Therapeutic Cancer Vaccination with Ex Vivo RNA-Transfected Dendritic Cells—An Update
by: Jan Dörrie, et al.
Published: (2020-01-01)

CSPG4-Specific CAR T Cells for High-Risk Childhood B Cell Precursor Leukemia
by: Dennis C. Harrer, et al.
Published: (2019-06-01)

RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma
by: Dennis C. Harrer, et al.
Published: (2017-08-01)

Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance
by: Manuel Wiesinger, et al.
Published: (2019-08-01)

NF-κB activation triggers NK-cell stimulation by monocyte-derived dendritic cells
by: Naomi C. Bosch, et al.
Published: (2019-12-01)

T-Cell Responses in Merkel Cell Carcinoma: Implications for Improved Immune Checkpoint Blockade and Other Therapeutic Options
by: Laura Gehrcken, et al.
Published: (2021-08-01)

Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells
by: Stefanie Hoyer, et al.
Published: (2015-01-01)

Highly Expressed miR-375 is not an Intracellular Oncogene in Merkel Cell Polyomavirus-Associated Merkel Cell Carcinoma
by: Kaiji Fan, et al.
Published: (2020-02-01)

Blood Eosinophilia is an on-Treatment Biomarker in Patients with Solid Tumors Undergoing Dendritic Cell Vaccination with Autologous Tumor-RNA
by: Alvaro Moreira, et al.
Published: (2020-03-01)

Just one position-independent lysine residue can direct MelanA into proteasomal degradation following N-terminal fusion of ubiquitin.
by: Christian Setz, et al.
Published: (2013-01-01)

CARs: Beyond T Cells and T Cell-Derived Signaling Domains
by: Nico M. Sievers, et al.
Published: (2020-05-01)

The Generation of CAR-Transfected Natural Killer T Cells for the Immunotherapy of Melanoma
by: Bianca Simon, et al.
Published: (2018-08-01)

Merkel Cell Polyomavirus and Merkel Cell Carcinoma
by: Valeria Pietropaolo, et al.
Published: (2020-07-01)

Merkel Cell Polyomavirus and Merkel Cell Carcinoma, France
by: Vincent Foulongne, et al.
Published: (2008-09-01)

Robust Production of Merkel Cell Polyomavirus Oncogene Specific T Cells From Healthy Donors for Adoptive Transfer
by: Sarah I. Davies, et al.
Published: (2020-12-01)

Arming T Cells with a gp100-Specific TCR and a CSPG4-Specific CAR Using Combined DNA- and RNA-Based Receptor Transfer
by: Bianca Simon, et al.
Published: (2019-05-01)

Merkel Cells
Published: (2008-09-01)

DETECTing Merkel Cell Polyomavirus in Merkel Tumors
by: Reety Arora, et al.
Published: (2020-02-01)

Merkel Cell Polyomavirus Strains in Patients with Merkel Cell Carcinoma
by: Antoine Touzé, et al.
Published: (2009-06-01)

Merkel cell polyomavirus in Merkel cell carcinoma of Italian patients
by: Migliano Emilia, et al.
Published: (2011-03-01)

Effects of Merkel cell polyomavirus T antigen expression on cell transformation of Merkel cells
by: Adzahar, Noor Suhana Binti
Published: (2016)

Merkel Cell Polyomavirus DNA in Persons without Merkel Cell Carcinoma
by: Ulrike Wieland, et al.
Published: (2009-09-01)

From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis
by: Nathan A. Krump, et al.
Published: (2021-09-01)

Merkel Cell Carcinoma
by: Elena Dellambra, et al.
Published: (2021-06-01)

Merkel cell carcinoma
by: Koljonen Virve
Published: (2006-02-01)

Serum Antibodies Against the Oncogenic Merkel Cell Polyomavirus Detected by an Innovative Immunological Assay With Mimotopes in Healthy Subjects
by: Chiara Mazziotta, et al.
Published: (2021-06-01)

Human adenovirus-specific γ/δ and CD8+ T cells generated by T-cell receptor transfection to treat adenovirus infection after allogeneic stem cell transplantation.
by: Jan Dörrie, et al.
Published: (2014-01-01)

Molecular Profiling of Merkel Cell Polyomavirus-Associated Merkel Cell Carcinoma and Cutaneous Melanoma
by: Attila Mokánszki, et al.
Published: (2021-02-01)

Understanding the role of Merkel cell polyomavirus oncoproteins in the cellular transformation of mammalian Merkel cells
by: Knight, Laura M.
Published: (2014)

Characterization of a Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cell Line CVG-1
by: Celestino Velásquez, et al.
Published: (2018-04-01)

Histogenesis of Merkel cell carcinoma
by: Kervarrec, Thibault
Published: (2020)

Response of Merkel cell polyomavirus-positive merkel cell carcinoma xenografts to a survivin inhibitor.
by: Lindsay R Dresang, et al.
Published: (2013-01-01)

Histological, Immunohistological, and Clinical Features of Merkel Cell Carcinoma in Correlation to Merkel Cell Polyomavirus Status
by: T. Jaeger, et al.
Published: (2012-01-01)

Merkel Cell Polyomavirus T Antigens Induce Merkel Cell-Like Differentiation in GLI1-Expressing Epithelial Cells
by: Thibault Kervarrec, et al.
Published: (2020-07-01)

Merkel cell polyomavirus and Langerhans cell neoplasm
by: Ichiro Murakami, et al.
Published: (2018-08-01)

Which Are the Cells of Origin in Merkel Cell Carcinoma?
by: Thomas Tilling, et al.
Published: (2012-01-01)

Identification of Merkel cell polyomavirus in Merkel cell carcinoma tissue: case report of a Taiwanese patient
by: Wen-Tsao Ho, et al.
Published: (2010-12-01)

Merkel Cells Release Glutamate Following Mechanical Stimulation: Implication of Glutamate in the Merkel Cell-Neurite Complex
by: Asuka Higashikawa, et al.
Published: (2019-06-01)

Promoter activity of Merkel cell Polyomavirus variants in human dermal fibroblasts and a Merkel cell carcinoma cell line
by: Ibrahim Abdulsalam, et al.
Published: (2020-04-01)