Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson’s Disease
Many clinical symptoms of sporadic Parkinson’s disease (sPD) cannot be completely explained by a lesion of the simple typical extrapyramidal circuit between the striatum and substantia nigra. Therefore, this study aimed to explore the new potential damaged pathogenesis of other brain regions associa...
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doaj-3b4c2d4c5bb8448fb69b0ffeeb4b01592021-05-31T07:17:28ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-05-011310.3389/fnagi.2021.650371650371Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson’s DiseaseXia Deng0Zheng Liu1Qin Kang2Lin Lu3Yu Zhu4Renshi Xu5Renshi Xu6Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Neurology, Jiangxi Provincial People’s Hospital, The Affiliated People’s Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Jiangxi Provincial People’s Hospital, The Affiliated People’s Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Neurology, Jiangxi Provincial People’s Hospital, The Affiliated People’s Hospital of Nanchang University, Nanchang, ChinaMany clinical symptoms of sporadic Parkinson’s disease (sPD) cannot be completely explained by a lesion of the simple typical extrapyramidal circuit between the striatum and substantia nigra. Therefore, this study aimed to explore the new potential damaged pathogenesis of other brain regions associated with the multiple and complex clinical symptoms of sPD through magnetic resonance imaging (MRI). A total of 65 patients with mid-stage sPD and 35 healthy controls were recruited in this study. Cortical structural connectivity was assessed by seed-based analysis using the vertex-based morphology of MRI. Seven different clusters in the brain regions of cortical thickness thinning derived from the regression analysis using brain size as covariates between sPD and control were selected as seeds. Results showed that the significant alteration of cortical structural connectivity mainly occurred in the bilateral frontal orbital, opercular, triangular, precentral, rectus, supplementary-motor, temporal pole, angular, Heschl, parietal, supramarginal, postcentral, precuneus, occipital, lingual, cuneus, Rolandic-opercular, cingulum, parahippocampal, calcarine, olfactory, insula, paracentral-lobule, and fusiform regions at the mid-stage of sPD. These findings suggested that the extensive alteration of cortical structural connectivity is one of possible pathogenesis resulting in the multiple and complex clinical symptoms in sPD.https://www.frontiersin.org/articles/10.3389/fnagi.2021.650371/fullSporadic Parkinson’s diseasemagnetic resonance imagingcortical structural connectivitypathogenesisbrain |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xia Deng Zheng Liu Qin Kang Lin Lu Yu Zhu Renshi Xu Renshi Xu |
spellingShingle |
Xia Deng Zheng Liu Qin Kang Lin Lu Yu Zhu Renshi Xu Renshi Xu Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson’s Disease Frontiers in Aging Neuroscience Sporadic Parkinson’s disease magnetic resonance imaging cortical structural connectivity pathogenesis brain |
author_facet |
Xia Deng Zheng Liu Qin Kang Lin Lu Yu Zhu Renshi Xu Renshi Xu |
author_sort |
Xia Deng |
title |
Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson’s Disease |
title_short |
Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson’s Disease |
title_full |
Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson’s Disease |
title_fullStr |
Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson’s Disease |
title_full_unstemmed |
Cortical Structural Connectivity Alterations and Potential Pathogenesis in Mid-Stage Sporadic Parkinson’s Disease |
title_sort |
cortical structural connectivity alterations and potential pathogenesis in mid-stage sporadic parkinson’s disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2021-05-01 |
description |
Many clinical symptoms of sporadic Parkinson’s disease (sPD) cannot be completely explained by a lesion of the simple typical extrapyramidal circuit between the striatum and substantia nigra. Therefore, this study aimed to explore the new potential damaged pathogenesis of other brain regions associated with the multiple and complex clinical symptoms of sPD through magnetic resonance imaging (MRI). A total of 65 patients with mid-stage sPD and 35 healthy controls were recruited in this study. Cortical structural connectivity was assessed by seed-based analysis using the vertex-based morphology of MRI. Seven different clusters in the brain regions of cortical thickness thinning derived from the regression analysis using brain size as covariates between sPD and control were selected as seeds. Results showed that the significant alteration of cortical structural connectivity mainly occurred in the bilateral frontal orbital, opercular, triangular, precentral, rectus, supplementary-motor, temporal pole, angular, Heschl, parietal, supramarginal, postcentral, precuneus, occipital, lingual, cuneus, Rolandic-opercular, cingulum, parahippocampal, calcarine, olfactory, insula, paracentral-lobule, and fusiform regions at the mid-stage of sPD. These findings suggested that the extensive alteration of cortical structural connectivity is one of possible pathogenesis resulting in the multiple and complex clinical symptoms in sPD. |
topic |
Sporadic Parkinson’s disease magnetic resonance imaging cortical structural connectivity pathogenesis brain |
url |
https://www.frontiersin.org/articles/10.3389/fnagi.2021.650371/full |
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