Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines
In this work, we showed the synthesis of zinc oxide nanoparticles (ZnO NPs) using leaf extract of Punica granatum. Characterization results showed the synthesis of stable ZnO NPs with average size of 7 nm. Fourier transform infrared (FT-IR) and zeta potential results confirmed the capping of ZnO NPs...
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Online Access: | https://doi.org/10.1515/gps-2020-0007 |
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doaj-3b5d34874d9a4be4b939450d9fc181362021-10-02T19:16:32ZengDe GruyterGreen Processing and Synthesis2191-95422191-95502019-12-0191566210.1515/gps-2020-0007gps-2020-0007Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell linesLiu Zuliang0Chen Fang1Lu Zhongde2Department of Pediatrics, Jiyang County People’s Hospital, Jiyang 251400, Shandong Province, ChinaDepartment of Pediatrics, Jiyang County People’s Hospital, Jiyang 251400, Shandong Province, ChinaDepartment of Pediatrics, Jiyang County People’s Hospital, Jiyang 251400, Shandong Province, ChinaIn this work, we showed the synthesis of zinc oxide nanoparticles (ZnO NPs) using leaf extract of Punica granatum. Characterization results showed the synthesis of stable ZnO NPs with average size of 7 nm. Fourier transform infrared (FT-IR) and zeta potential results confirmed the capping of ZnO NPs with plant extract polyphenols. X-ray diffraction (XRD) and selected area electron diffraction (SAED) examinations showed the crystalline nature of prepared ZnO NPs. Further, the cytotoxic properties of the green synthesized ZnO NPs are examined against pediatric leukemia cells and the morphology of cells was studies under microscope. The results of cytotoxicity and microscopic images revealed the dose dependent cytotoxicity, indicating their prospects for the development of novel techniques and materials for pediatric leukemia cancer therapy.https://doi.org/10.1515/gps-2020-0007zno npscytotoxicitypediatric cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liu Zuliang Chen Fang Lu Zhongde |
spellingShingle |
Liu Zuliang Chen Fang Lu Zhongde Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines Green Processing and Synthesis zno nps cytotoxicity pediatric cells |
author_facet |
Liu Zuliang Chen Fang Lu Zhongde |
author_sort |
Liu Zuliang |
title |
Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines |
title_short |
Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines |
title_full |
Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines |
title_fullStr |
Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines |
title_full_unstemmed |
Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines |
title_sort |
biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines |
publisher |
De Gruyter |
series |
Green Processing and Synthesis |
issn |
2191-9542 2191-9550 |
publishDate |
2019-12-01 |
description |
In this work, we showed the synthesis of zinc oxide nanoparticles (ZnO NPs) using leaf extract of Punica granatum. Characterization results showed the synthesis of stable ZnO NPs with average size of 7 nm. Fourier transform infrared (FT-IR) and zeta potential results confirmed the capping of ZnO NPs with plant extract polyphenols. X-ray diffraction (XRD) and selected area electron diffraction (SAED) examinations showed the crystalline nature of prepared ZnO NPs. Further, the cytotoxic properties of the green synthesized ZnO NPs are examined against pediatric leukemia cells and the morphology of cells was studies under microscope. The results of cytotoxicity and microscopic images revealed the dose dependent cytotoxicity, indicating their prospects for the development of novel techniques and materials for pediatric leukemia cancer therapy. |
topic |
zno nps cytotoxicity pediatric cells |
url |
https://doi.org/10.1515/gps-2020-0007 |
work_keys_str_mv |
AT liuzuliang biofabricationofzincoxidenanoparticlescharacterizationandcytotoxicityagainstpediatricleukemiacelllines AT chenfang biofabricationofzincoxidenanoparticlescharacterizationandcytotoxicityagainstpediatricleukemiacelllines AT luzhongde biofabricationofzincoxidenanoparticlescharacterizationandcytotoxicityagainstpediatricleukemiacelllines |
_version_ |
1716847418312491008 |