Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines

Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines

In this work, we showed the synthesis of zinc oxide nanoparticles (ZnO NPs) using leaf extract of Punica granatum. Characterization results showed the synthesis of stable ZnO NPs with average size of 7 nm. Fourier transform infrared (FT-IR) and zeta potential results confirmed the capping of ZnO NPs...

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Main Authors: Liu Zuliang, Chen Fang, Lu Zhongde
Format: Article
Language:English
Published: De Gruyter 2019-12-01
Series:Green Processing and Synthesis
Subjects:
zno nps
cytotoxicity
pediatric cells
Online Access:https://doi.org/10.1515/gps-2020-0007
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spelling doaj-3b5d34874d9a4be4b939450d9fc181362021-10-02T19:16:32ZengDe GruyterGreen Processing and Synthesis2191-95422191-95502019-12-0191566210.1515/gps-2020-0007gps-2020-0007Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell linesLiu Zuliang0Chen Fang1Lu Zhongde2Department of Pediatrics, Jiyang County People’s Hospital, Jiyang 251400, Shandong Province, ChinaDepartment of Pediatrics, Jiyang County People’s Hospital, Jiyang 251400, Shandong Province, ChinaDepartment of Pediatrics, Jiyang County People’s Hospital, Jiyang 251400, Shandong Province, ChinaIn this work, we showed the synthesis of zinc oxide nanoparticles (ZnO NPs) using leaf extract of Punica granatum. Characterization results showed the synthesis of stable ZnO NPs with average size of 7 nm. Fourier transform infrared (FT-IR) and zeta potential results confirmed the capping of ZnO NPs with plant extract polyphenols. X-ray diffraction (XRD) and selected area electron diffraction (SAED) examinations showed the crystalline nature of prepared ZnO NPs. Further, the cytotoxic properties of the green synthesized ZnO NPs are examined against pediatric leukemia cells and the morphology of cells was studies under microscope. The results of cytotoxicity and microscopic images revealed the dose dependent cytotoxicity, indicating their prospects for the development of novel techniques and materials for pediatric leukemia cancer therapy.https://doi.org/10.1515/gps-2020-0007zno npscytotoxicitypediatric cells
collection DOAJ
language English
format Article
sources DOAJ
author Liu Zuliang
Chen Fang
Lu Zhongde
spellingShingle Liu Zuliang
Chen Fang
Lu Zhongde
Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines
Green Processing and Synthesis
zno nps
cytotoxicity
pediatric cells
author_facet Liu Zuliang
Chen Fang
Lu Zhongde
author_sort Liu Zuliang
title Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines
title_short Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines
title_full Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines
title_fullStr Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines
title_full_unstemmed Biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines
title_sort biofabrication of zinc oxide nanoparticles, characterization and cytotoxicity against pediatric leukemia cell lines
publisher De Gruyter
series Green Processing and Synthesis
issn 2191-9542
2191-9550
publishDate 2019-12-01
description In this work, we showed the synthesis of zinc oxide nanoparticles (ZnO NPs) using leaf extract of Punica granatum. Characterization results showed the synthesis of stable ZnO NPs with average size of 7 nm. Fourier transform infrared (FT-IR) and zeta potential results confirmed the capping of ZnO NPs with plant extract polyphenols. X-ray diffraction (XRD) and selected area electron diffraction (SAED) examinations showed the crystalline nature of prepared ZnO NPs. Further, the cytotoxic properties of the green synthesized ZnO NPs are examined against pediatric leukemia cells and the morphology of cells was studies under microscope. The results of cytotoxicity and microscopic images revealed the dose dependent cytotoxicity, indicating their prospects for the development of novel techniques and materials for pediatric leukemia cancer therapy.
topic zno nps
cytotoxicity
pediatric cells
url https://doi.org/10.1515/gps-2020-0007
work_keys_str_mv AT liuzuliang biofabricationofzincoxidenanoparticlescharacterizationandcytotoxicityagainstpediatricleukemiacelllines
AT chenfang biofabricationofzincoxidenanoparticlescharacterizationandcytotoxicityagainstpediatricleukemiacelllines
AT luzhongde biofabricationofzincoxidenanoparticlescharacterizationandcytotoxicityagainstpediatricleukemiacelllines
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