Systems biology derived source-sink mechanism of BMP gradient formation

Systems biology derived source-sink mechanism of BMP gradient formation

A morphogen gradient of Bone Morphogenetic Protein (BMP) signaling patterns the dorsoventral embryonic axis of vertebrates and invertebrates. The prevailing view in vertebrates for BMP gradient formation is through a counter-gradient of BMP antagonists, often along with ligand shuttling to generate...

Full description

Bibliographic Details
Main Authors:	Joseph Zinski, Ye Bu, Xu Wang, Wei Dou, David Umulis, Mary C Mullins
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2017-08-01
Series:	eLife
Subjects:	BMP signaling mathematical model-based computational screens quantitative analysis BMP diffusion BMP shuttling counter-gradient
Online Access:	https://elifesciences.org/articles/22199

Similar Items

Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning
by: Autumn P Pomreinke, et al.
Published: (2017-08-01)

BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis
by: Hyung-Seok Kim, et al.
Published: (2019-09-01)

BMP9 et BMP10 dans le remodelage vasculaire périnatal
by: Levet, Sandrine
Published: (2013)

Identification of BMP2 and BMP7 genes and association of their SNPs with growth traits in the hard clam (Meretrix meretrix)
by: G Pan, et al.
Published: (2019-08-01)

The Role of BMP Signaling in Osteoclast Regulation
by: Brian Heubel, et al.
Published: (2021-06-01)

Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation
by: Jennifer Winstanley, et al.
Published: (2015-02-01)

Emerging roles of BMP9 and BMP10 in hereditary hemorrhagic telangiectasia
by: Emmanuelle eTillet, et al.
Published: (2015-01-01)

The culture microenvironment of juvenile idiopathic arthritis synovial fibroblasts is favorable for endochondral bone formation through BMP4 and repressed by chondrocytes
by: Megan M. Simonds, et al.
Published: (2021-05-01)

Analyse des profils d'expression génique au cours de la différenciation gonadique chez le poulet : étude fonctionnelle d'un cas particulier : bMP 4 (bone morphogenetic protein)
by: Carré, Gwenn-Aël
Published: (2010)

BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer
by: Marie Ouarné, et al.
Published: (2018-08-01)

Could BMP-2 and BMP-7 be biomarkers of coronary artery disease? A pilot clinical study
by: Saeed Nazemi, et al.
Published: (2018-05-01)

Analysis of BMP4 and BMP7 signaling in breast cancer cells unveils time-dependent transcription patterns and highlights a common synexpression group of genes
by: Rodriguez-Martinez Alejandra, et al.
Published: (2011-11-01)

BMP antagonists in tissue development and disease
by: Annkatrin Correns, et al.
Published: (2021-08-01)

Deciphering the Role of Kekkon5 in BMP signaling and Cell Junction Biology
by: Menon, Harita
Published: (2013)

The effects of mouse ovarian granulosa cell function and related gene expression by suppressing BMP/Smad signaling pathway
by: Li Zhang, et al.
Published: (2018-09-01)

Synapse Elimination Triggered by BMP4 Exocytosis and Presynaptic BMP Receptor Activation
by: Takahito Higashi, et al.
Published: (2018-01-01)

Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation
by: Megan M. Simonds, et al.
Published: (2020-11-01)

FID Fast Image Display for (.BMP & .PCX) Images
by: Rawaa Qasha, et al.
Published: (2004-05-01)

Analyse von BMP2 und BMP2-Derivaten der TGF-β-Familie als potentielles Therapeutikum im Multiplen Myelom
by: Lagler, Charlotte
Published: (2017)

The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology
by: Ljuba C. Ponomarev, et al.
Published: (2021-06-01)

Source and Carrier Effect on the Bioactivity of BMP Bio-implants
by: Di Lullo, Sylvie
Published: (2013)

Source and Carrier Effect on the Bioactivity of BMP Bio-implants
by: Di Lullo, Sylvie
Published: (2013)

BMP 2 and BMP 4 genes expression in the development of the embryo heart in induced gestational diabetes of C57BL/6 mice
by: Fatemeh Ghasemzadeh, et al.
Published: (2018-08-01)

The Wnt and BMP Families of Signaling Morphogens at the Vertebrate Neuromuscular Junction
by: Juan P. Henríquez, et al.
Published: (2011-12-01)

MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons
by: Caitlin Engelhard, et al.
Published: (2013-09-01)

A Cyclic BMP-2 Peptide Upregulates BMP-2 Protein-Induced Cell Signaling in Myogenic Cells
by: Vijaya Narasimha Gudivada, et al.
Published: (2021-07-01)

Matrix-immobilized BMP-2 on microcontact printed fibronectin as in vitro tool to study BMP-mediated signaling and cell migration
by: Kristin eHauff, et al.
Published: (2015-05-01)

Optogenetic investigation of BMP target gene expression diversity
by: Katherine W Rogers, et al.
Published: (2020-11-01)

Die Rolle der Bone-Morphogenetic-Proteine (BMP) -2 und -5 in der adulten humanen Niere und bei der hypertensiven Nephrosklerose
by: Bevanda, Jelena
Published: (2015)

Nasal Septum Deviation as the Consequence of BMP-Controlled Changes to Cartilage Properties
by: Pranidhi Baddam, et al.
Published: (2021-06-01)

The Effect of Uphill and Downhill Exercise Training on Myogenic Mechanism of Wnt/BMP Signaling in the Skeletal Muscle of Aged Rats
by: Yong-Uoo Chang, et al.
Published: (2019-05-01)

Recapitulation of growth factor-enriched microenvironment via BMP receptor activating hydrogel
by: Li, J., et al.
Published: (2023)

Application of the Analytic Hierarchy Process Optimization Algorithm in Best Management Practice Selection
by: Young, Kevin D.
Published: (2014)

Dp412e : une nouvelle isoforme embryonnaire humaine de la dystrophine
by: Massouridès, Emmanuelle
Published: (2015)

Contribution au développement de substituts osseux auto-réticulants en ingénierie tissulaire osseuse maxillo-faciale
by: Toure, Amadou
Published: (2018)

Variants in <i>BMP7</i> and <i>BMP15</i> 3’-<i>UTR</i>s Associated with Reproductive Traits in a Large White Pig Population
by: Hang Yin, et al.
Published: (2019-11-01)

BMP-2 shows characteristic extracellular patterns in osteoarthritic cartilage: a preliminary report
by: Pester, Julia K., et al.
Published: (2013-08-01)

BMP-2/β-TCP Local Delivery for Bone Regeneration in MRONJ-Like Mouse Model
by: Akihiro Mikai, et al.
Published: (2020-09-01)

BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model
by: SongTing Shi, et al.
Published: (2011-02-01)

Reparo do defeito alveolar com proteína morfogenética óssea (rhBMP-2) em pacientes com fissura labiopalatina
by: Roberta Martinelli Carvalho
Published: (2011)