Effects of Selenium-Enriched Probiotics on Heart Lesions by Influencing the mRNA Expressions of Selenoproteins and Heat Shock Proteins in Heat Stressed Broiler Chickens

• Main Author: Alam Zeb Khan1,2, Shahnawaz Kumbhar1, Muhammad Hamid1, Samreen Afzal3, Fahmida Parveen1, Yunhuan Liu1, Hao Shu1, Berhe Mekonnen Mengistu1 and Kehe Huang1*
• Format: Article
• Language: English
• Published: University of Agriculture, Faisalabad 2016-11-01
• Series: Pakistan Veterinary Journal
• Subjects: Broiler chickens; Heart lesions; Heat shock proteins; Heat stress; Selenium-enriched probiotics; Selenoproteins
• Online Access: http://pvj.com.pk/pdf-files/36_4/460-464.pdf

Selenium is one of the most vital trace elements regulating various body functions. Herein, we observe the effects of selenium-enriched probiotics on heart lesion in broiler chickens under high ambient temperature and explore the underlying mechanisms. Four different groups of broiler chickens were fed a corn-soybean basal diet having no Se supplementation (Con group), basal diet with the addition of probiotics (P group), a basal diet with Se supplementation in the form of sodium selenite (SS group, 0.30mg Se/kg) and basal diet with the addition of selenium enriched probiotics (SP group, 0.30mg Se/kg). The results showed that P, SS, or SP supplementation significantly (P<0.05) up-regulated mRNA expression of selenoproteins (GPx1, GPx4) and down-regulated heat shock proteins (Hsp60, Hsp70 and Hsp90) in heart as compared to Con, P and SS diets. Herein, we suggest that SP product can serve as a feasible nutritive supplement, capable of protecting the heart from toxic effect of oxidative stress in summer season.