Curative effect of transbronchoscopic perfusion combined with conventional chemotherapy on multi-drug resistant tuberculosis
Objective: To analyze the curative effect of transbronchoscopic perfusion combined with conventional chemotherapy on multi-drug resistant tuberculosis. Methods: A total of 70 patients with multi-drug resistant tuberculosis treated in our hospital between April 2012 and April 2015 were selected an...
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doaj-3b720a19b1284bfe86a6aa3bd4bea4462020-11-25T00:11:27ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372016-12-0122234043Curative effect of transbronchoscopic perfusion combined with conventional chemotherapy on multi-drug resistant tuberculosisYang Li03rd Ward of Pneumology Department, Shenyang Chest Hospital of Liaoning Province, Shenyang City, Liaoning Province, 110044, ChinaObjective: To analyze the curative effect of transbronchoscopic perfusion combined with conventional chemotherapy on multi-drug resistant tuberculosis. Methods: A total of 70 patients with multi-drug resistant tuberculosis treated in our hospital between April 2012 and April 2015 were selected and randomly divided into two groups, control group received conventional chemotherapy and observation group received transbronchoscopic perfusion + conventional chemotherapy. After treatment, negative conversion ratio of sputum mycobacterium tuberculosis, immune function, disease-specific indexes, oxidative stress indexes and liver function indexes were compared between two groups of patients. Results: After 6 months and 12 months of treatment, negative conversion ratio of sputum mycobacterium tuberculosis of observation group were significantly higher than those of control group; after 12 months of treatment, CD3+ , CD4+ , CD4+ /CD8+ , IgA, IgM and IgG levels in peripheral blood of observation group were significantly higher than those of control group while disease-specific indexes ADA and LDH content in serum were lower than those of control group; oxidative stress indexes TOS, MAOA and OSI content in serum were lower than those of control group while TAS and GSH-Px content were higher than those of control group; liver function indexes STB, ALP, ALT and AST content in serum were lower than those of control group while TP content was higher than that of control group. Conclusions: Transbronchoscopic perfusion combined with conventional chemotherapy can improve the treatment effectiveness, improve immune function as well as reduce oxidative stress and liver damage in patients with multi-drug resistant tuberculosis, and is advantageous in optimizing long-term treatment outcome.http://www.hnykdxxb.com/PDF/201623/11.pdfMulti-drug resistant tuberculosisTransbronchoscopic perfusionConventional chemotherapyOxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yang Li |
spellingShingle |
Yang Li Curative effect of transbronchoscopic perfusion combined with conventional chemotherapy on multi-drug resistant tuberculosis Journal of Hainan Medical University Multi-drug resistant tuberculosis Transbronchoscopic perfusion Conventional chemotherapy Oxidative stress |
author_facet |
Yang Li |
author_sort |
Yang Li |
title |
Curative effect of transbronchoscopic perfusion combined with conventional chemotherapy on multi-drug resistant tuberculosis |
title_short |
Curative effect of transbronchoscopic perfusion combined with conventional chemotherapy on multi-drug resistant tuberculosis |
title_full |
Curative effect of transbronchoscopic perfusion combined with conventional chemotherapy on multi-drug resistant tuberculosis |
title_fullStr |
Curative effect of transbronchoscopic perfusion combined with conventional chemotherapy on multi-drug resistant tuberculosis |
title_full_unstemmed |
Curative effect of transbronchoscopic perfusion combined with conventional chemotherapy on multi-drug resistant tuberculosis |
title_sort |
curative effect of transbronchoscopic perfusion combined with conventional chemotherapy on multi-drug resistant tuberculosis |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2016-12-01 |
description |
Objective: To analyze the curative effect of transbronchoscopic perfusion combined with
conventional chemotherapy on multi-drug resistant tuberculosis. Methods: A total of
70 patients with multi-drug resistant tuberculosis treated in our hospital between April
2012 and April 2015 were selected and randomly divided into two groups, control group
received conventional chemotherapy and observation group received transbronchoscopic
perfusion + conventional chemotherapy. After treatment, negative conversion ratio of
sputum mycobacterium tuberculosis, immune function, disease-specific indexes, oxidative
stress indexes and liver function indexes were compared between two groups of patients.
Results: After 6 months and 12 months of treatment, negative conversion ratio of sputum
mycobacterium tuberculosis of observation group were significantly higher than those of
control group; after 12 months of treatment, CD3+
, CD4+
, CD4+
/CD8+
, IgA, IgM and IgG
levels in peripheral blood of observation group were significantly higher than those of control
group while disease-specific indexes ADA and LDH content in serum were lower than those
of control group; oxidative stress indexes TOS, MAOA and OSI content in serum were lower
than those of control group while TAS and GSH-Px content were higher than those of control
group; liver function indexes STB, ALP, ALT and AST content in serum were lower than
those of control group while TP content was higher than that of control group. Conclusions:
Transbronchoscopic perfusion combined with conventional chemotherapy can improve the
treatment effectiveness, improve immune function as well as reduce oxidative stress and liver
damage in patients with multi-drug resistant tuberculosis, and is advantageous in optimizing
long-term treatment outcome. |
topic |
Multi-drug resistant tuberculosis Transbronchoscopic perfusion Conventional chemotherapy Oxidative stress |
url |
http://www.hnykdxxb.com/PDF/201623/11.pdf |
work_keys_str_mv |
AT yangli curativeeffectoftransbronchoscopicperfusioncombinedwithconventionalchemotherapyonmultidrugresistanttuberculosis |
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1725404017375313920 |