Phosphatidylinositol-glycan-phospholipase D is involved in neurodegeneration in prion disease.
PrPSc is formed from a normal glycosylphosphatidylinositol (GPI)-anchored prion protein (PrPC) by a posttranslational modification. Most GPI-anchored proteins have been shown to be cleaved by GPI phospholipases. Recently, GPI-phospholipase D (GPI-PLD) was shown to be a strictly specific enzyme for G...
Main Authors: | Jae-Kwang Jin, Byungki Jang, Hyoung Tae Jin, Eun-Kyoung Choi, Cha-Gyun Jung, Hiroyasu Akatsu, Jae-Il Kim, Richard I Carp, Yong-Sun Kim |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4395093?pdf=render |
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