CTCF binding protein and epigenetic regulations of genome
CTCF is a highly conserved DNA-binding protein involved in transcription regulation, chromatin insulation, genomic imprinting, X-chromosome inactivation, higher-order chromatin organization, and alternative splicing. These multifunctional properties of CTCF suggest an essential role in development a...
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Shahid Bahonar University of Kerman
2013-11-01
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Online Access: | https://jab.uk.ac.ir/article_1216_a4806f23089aa75ea1fb8e77197cbe18.pdf |
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doaj-3b8119c7d85b44ac9d4c8727f17b482d2020-11-25T03:54:56ZfasShahid Bahonar University of Kermanمجله بیوتکنولوژی کشاورزی2228-67052228-65002013-11-015311914210.22103/jab.2013.12161216CTCF binding protein and epigenetic regulations of genomeMohammad Reza Mohammad AbadiMahmoud Amiri RoudbarHamide Adel doustCTCF is a highly conserved DNA-binding protein involved in transcription regulation, chromatin insulation, genomic imprinting, X-chromosome inactivation, higher-order chromatin organization, and alternative splicing. These multifunctional properties of CTCF suggest an essential role in development and disease. CTCF is unique protein that known to mediate insulation function in vertebrates. Recent studies proposed that CTCF can be a heritable component in epigenetic and regulating the interaction between DNA methylation, higher-order chromatin structure, and developmentally regulated gene expression. In this review, we discuss roles of CTCF in these critical aspects of genome regulation. All information indicates that CTCF can emerge as a master weaver of the mammalian genome.https://jab.uk.ac.ir/article_1216_a4806f23089aa75ea1fb8e77197cbe18.pdfctcfepigeneticchromosome x inactivationinsulatorcancer |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Mohammad Reza Mohammad Abadi Mahmoud Amiri Roudbar Hamide Adel doust |
spellingShingle |
Mohammad Reza Mohammad Abadi Mahmoud Amiri Roudbar Hamide Adel doust CTCF binding protein and epigenetic regulations of genome مجله بیوتکنولوژی کشاورزی ctcf epigenetic chromosome x inactivation insulator cancer |
author_facet |
Mohammad Reza Mohammad Abadi Mahmoud Amiri Roudbar Hamide Adel doust |
author_sort |
Mohammad Reza Mohammad Abadi |
title |
CTCF binding protein and epigenetic regulations of genome |
title_short |
CTCF binding protein and epigenetic regulations of genome |
title_full |
CTCF binding protein and epigenetic regulations of genome |
title_fullStr |
CTCF binding protein and epigenetic regulations of genome |
title_full_unstemmed |
CTCF binding protein and epigenetic regulations of genome |
title_sort |
ctcf binding protein and epigenetic regulations of genome |
publisher |
Shahid Bahonar University of Kerman |
series |
مجله بیوتکنولوژی کشاورزی |
issn |
2228-6705 2228-6500 |
publishDate |
2013-11-01 |
description |
CTCF is a highly conserved DNA-binding protein involved in transcription regulation, chromatin insulation, genomic imprinting, X-chromosome inactivation, higher-order chromatin organization, and alternative splicing. These multifunctional properties of CTCF suggest an essential role in development and disease. CTCF is unique protein that known to mediate insulation function in vertebrates. Recent studies proposed that CTCF can be a heritable component in epigenetic and regulating the interaction between DNA methylation, higher-order chromatin structure, and developmentally regulated gene expression. In this review, we discuss roles of CTCF in these critical aspects of genome regulation. All information indicates that CTCF can emerge as a master weaver of the mammalian genome. |
topic |
ctcf epigenetic chromosome x inactivation insulator cancer |
url |
https://jab.uk.ac.ir/article_1216_a4806f23089aa75ea1fb8e77197cbe18.pdf |
work_keys_str_mv |
AT mohammadrezamohammadabadi ctcfbindingproteinandepigeneticregulationsofgenome AT mahmoudamiriroudbar ctcfbindingproteinandepigeneticregulationsofgenome AT hamideadeldoust ctcfbindingproteinandepigeneticregulationsofgenome |
_version_ |
1724471649935294464 |