Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data

Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data

Estimating direct and indirect effects of genotypes on phenotypes is important for genetic analyses such as Mendelian randomization. Here the authors compare five different methods to estimate direct and indirect genetic effects using summary results statistics that account for sample overlap.

Bibliographic Details
Main Authors: Nicole M. Warrington, Liang-Dar Hwang, Michel G. Nivard, David M. Evans
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25723-z
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spelling doaj-3b86a242695944458fd715e56be7d9632021-09-19T11:49:07ZengNature Publishing GroupNature Communications2041-17232021-09-0112111210.1038/s41467-021-25723-zEstimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results dataNicole M. Warrington0Liang-Dar Hwang1Michel G. Nivard2David M. Evans3Institute for Molecular Biosciences, The University of QueenslandInstitute for Molecular Biosciences, The University of QueenslandDepartment of Biological Psychology, Faculty of Behaviour and Movement Sciences, VU UniversityInstitute for Molecular Biosciences, The University of QueenslandEstimating direct and indirect effects of genotypes on phenotypes is important for genetic analyses such as Mendelian randomization. Here the authors compare five different methods to estimate direct and indirect genetic effects using summary results statistics that account for sample overlap.https://doi.org/10.1038/s41467-021-25723-z
collection DOAJ
language English
format Article
sources DOAJ
author Nicole M. Warrington
Liang-Dar Hwang
Michel G. Nivard
David M. Evans
spellingShingle Nicole M. Warrington
Liang-Dar Hwang
Michel G. Nivard
David M. Evans
Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
Nature Communications
author_facet Nicole M. Warrington
Liang-Dar Hwang
Michel G. Nivard
David M. Evans
author_sort Nicole M. Warrington
title Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
title_short Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
title_full Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
title_fullStr Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
title_full_unstemmed Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
title_sort estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-09-01
description Estimating direct and indirect effects of genotypes on phenotypes is important for genetic analyses such as Mendelian randomization. Here the authors compare five different methods to estimate direct and indirect genetic effects using summary results statistics that account for sample overlap.
url https://doi.org/10.1038/s41467-021-25723-z
work_keys_str_mv AT nicolemwarrington estimatingdirectandindirectgeneticeffectsonoffspringphenotypesusinggenomewidesummaryresultsdata
AT liangdarhwang estimatingdirectandindirectgeneticeffectsonoffspringphenotypesusinggenomewidesummaryresultsdata
AT michelgnivard estimatingdirectandindirectgeneticeffectsonoffspringphenotypesusinggenomewidesummaryresultsdata
AT davidmevans estimatingdirectandindirectgeneticeffectsonoffspringphenotypesusinggenomewidesummaryresultsdata
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