Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
Estimating direct and indirect effects of genotypes on phenotypes is important for genetic analyses such as Mendelian randomization. Here the authors compare five different methods to estimate direct and indirect genetic effects using summary results statistics that account for sample overlap.
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Nature Publishing Group
2021-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-25723-z |
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doaj-3b86a242695944458fd715e56be7d9632021-09-19T11:49:07ZengNature Publishing GroupNature Communications2041-17232021-09-0112111210.1038/s41467-021-25723-zEstimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results dataNicole M. Warrington0Liang-Dar Hwang1Michel G. Nivard2David M. Evans3Institute for Molecular Biosciences, The University of QueenslandInstitute for Molecular Biosciences, The University of QueenslandDepartment of Biological Psychology, Faculty of Behaviour and Movement Sciences, VU UniversityInstitute for Molecular Biosciences, The University of QueenslandEstimating direct and indirect effects of genotypes on phenotypes is important for genetic analyses such as Mendelian randomization. Here the authors compare five different methods to estimate direct and indirect genetic effects using summary results statistics that account for sample overlap.https://doi.org/10.1038/s41467-021-25723-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicole M. Warrington Liang-Dar Hwang Michel G. Nivard David M. Evans |
spellingShingle |
Nicole M. Warrington Liang-Dar Hwang Michel G. Nivard David M. Evans Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data Nature Communications |
author_facet |
Nicole M. Warrington Liang-Dar Hwang Michel G. Nivard David M. Evans |
author_sort |
Nicole M. Warrington |
title |
Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data |
title_short |
Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data |
title_full |
Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data |
title_fullStr |
Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data |
title_full_unstemmed |
Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data |
title_sort |
estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2021-09-01 |
description |
Estimating direct and indirect effects of genotypes on phenotypes is important for genetic analyses such as Mendelian randomization. Here the authors compare five different methods to estimate direct and indirect genetic effects using summary results statistics that account for sample overlap. |
url |
https://doi.org/10.1038/s41467-021-25723-z |
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1717375473559797760 |