Factors associated with distant metastasis in pediatric thyroid cancer: evaluation of the SEER database
Objectives: Controversies regarding factors associated with distant metastasis in pediatric thyroid cancer remain among the scientific community. The aim of this study was to investigate factors influencing distant metastasis in pediatric thyroid cancer. Methods: We reviewed 1376 patients (aged 2 t...
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Bioscientifica
2019-01-01
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doaj-3b94246f44254050bf7bd0416bdfee352020-11-24T20:53:07ZengBioscientificaEndocrine Connections2049-36142049-36142019-01-01827885https://doi.org/10.1530/EC-18-0441Factors associated with distant metastasis in pediatric thyroid cancer: evaluation of the SEER databaseZeming Liu0Di Hu1Yihui Huang2Sichao Chen3Wen Zeng4Ling Zhou5Wei Zhou6Min Wang7Haifeng Feng8Wei Wei9Chao Zhang10Danyang Chen11Liang Guo12Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Pediatrics, St John Hospital and Medical Center, Detroit, Michigan, USADepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, ChinaDepartment of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, ChinaObjectives: Controversies regarding factors associated with distant metastasis in pediatric thyroid cancer remain among the scientific community. The aim of this study was to investigate factors influencing distant metastasis in pediatric thyroid cancer. Methods: We reviewed 1376 patients (aged 2 to 18 years) with thyroid cancer treated between 2003 and 2014. Data collected and analyzed included sex, race, age at diagnosis, year of diagnosis, pathological type, number of tumor foci, tumor extension, T-stage, N-stage, surgical procedure and radiation. Univariate and multivariate analyses were conducted to evaluate factors influencing distant metastasis of pediatric thyroid cancer. Results: In the univariate analysis, factors influencing distant metastasis of thyroid cancer were age at diagnosis (P < 0.001), N-stage (P < 0.001), number of tumor foci (P = 0.003), tumor extension (P < 0.001) and T-stage (T1 vs T2 (P = 0.803), T3 (P < 0.001) and T4 (P < 0.001)). In multivariate analysis, factors influencing distant metastasis of thyroid cancer were age at diagnosis (P = 0.001), N-stage (P < 0.001) and T-stage (T1 vs T3 (P = 0.036) and T4 (P < 0.001)). Sex, race, year of diagnosis, pathological type, number of tumor foci, tumor extension, surgical procedure and radiation had no significant influence on distant metastasis (all P > 0.05). Furthermore, according to chi-squared test, younger pediatric thyroid cancer patients with higher T- and N-stages are more likely to have distant metastasis. Conclusion: Age at diagnosis, T-stage and N-stage influence distant metastasis of thyroid cancer patients aged 2 to 18 years; accordingly, more radical treatments may need to be used for patients with those risk elements.https://ec.bioscientifica.com/view/journals/ec/8/2/EC-18-0441.xmlendocrine malignant tumorthyroid cancerchildrendistant metastasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zeming Liu Di Hu Yihui Huang Sichao Chen Wen Zeng Ling Zhou Wei Zhou Min Wang Haifeng Feng Wei Wei Chao Zhang Danyang Chen Liang Guo |
spellingShingle |
Zeming Liu Di Hu Yihui Huang Sichao Chen Wen Zeng Ling Zhou Wei Zhou Min Wang Haifeng Feng Wei Wei Chao Zhang Danyang Chen Liang Guo Factors associated with distant metastasis in pediatric thyroid cancer: evaluation of the SEER database Endocrine Connections endocrine malignant tumor thyroid cancer children distant metastasis |
author_facet |
Zeming Liu Di Hu Yihui Huang Sichao Chen Wen Zeng Ling Zhou Wei Zhou Min Wang Haifeng Feng Wei Wei Chao Zhang Danyang Chen Liang Guo |
author_sort |
Zeming Liu |
title |
Factors associated with distant metastasis in pediatric thyroid cancer: evaluation of the SEER database |
title_short |
Factors associated with distant metastasis in pediatric thyroid cancer: evaluation of the SEER database |
title_full |
Factors associated with distant metastasis in pediatric thyroid cancer: evaluation of the SEER database |
title_fullStr |
Factors associated with distant metastasis in pediatric thyroid cancer: evaluation of the SEER database |
title_full_unstemmed |
Factors associated with distant metastasis in pediatric thyroid cancer: evaluation of the SEER database |
title_sort |
factors associated with distant metastasis in pediatric thyroid cancer: evaluation of the seer database |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2019-01-01 |
description |
Objectives: Controversies regarding factors associated with distant metastasis in pediatric thyroid cancer remain among the scientific community. The aim of this study was to investigate factors influencing distant metastasis in pediatric thyroid cancer.
Methods: We reviewed 1376 patients (aged 2 to 18 years) with thyroid cancer treated between 2003 and 2014. Data collected and analyzed included sex, race, age at diagnosis, year of diagnosis, pathological type, number of tumor foci, tumor extension, T-stage, N-stage, surgical procedure and radiation. Univariate and multivariate analyses were conducted to evaluate factors influencing distant metastasis of pediatric thyroid cancer.
Results: In the univariate analysis, factors influencing distant metastasis of thyroid cancer were age at diagnosis (P < 0.001), N-stage (P < 0.001), number of tumor foci (P = 0.003), tumor extension (P < 0.001) and T-stage (T1 vs T2 (P = 0.803), T3 (P < 0.001) and T4 (P < 0.001)). In multivariate analysis, factors influencing distant metastasis of thyroid cancer were age at diagnosis (P = 0.001), N-stage (P < 0.001) and T-stage (T1 vs T3 (P = 0.036) and T4 (P < 0.001)). Sex, race, year of diagnosis, pathological type, number of tumor foci, tumor extension, surgical procedure and radiation had no significant influence on distant metastasis (all P > 0.05). Furthermore, according to chi-squared test, younger pediatric thyroid cancer patients with higher T- and N-stages are more likely to have distant metastasis.
Conclusion: Age at diagnosis, T-stage and N-stage influence distant metastasis of thyroid cancer patients aged 2 to 18 years; accordingly, more radical treatments may need to be used for patients with those risk elements. |
topic |
endocrine malignant tumor thyroid cancer children distant metastasis |
url |
https://ec.bioscientifica.com/view/journals/ec/8/2/EC-18-0441.xml |
work_keys_str_mv |
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