Phenolic profile and anti-inflammatory activity of four Moroccan date (Phoenix dactylifera L.) seed varieties
Date (Phoenix dactylifera L.) seeds are seen as good drug to cure rheumatoid arthritis and asthma in Moroccan traditional medicine. The present research aimed to study the anti-inflammatory effect, of methanol extract of different date seed varieties using membrane stabilizing effect, nitric oxide r...
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doaj-3b980ee37282412fac7354a901e4b6432020-11-25T02:07:07ZengElsevierHeliyon2405-84402020-02-0162e03436Phenolic profile and anti-inflammatory activity of four Moroccan date (Phoenix dactylifera L.) seed varietiesEimad dine Tariq Bouhlali0Abdelbasset Hmidani1Bouchra Bourkhis2Tarik Khouya3Mhamed Ramchoun4Younes Filali-Zegzouti5Chakib Alem6National Institute of Agronomic Research Regional Center of Errachidia, Morocco; Biochemistry of Natural Products Team, Faculty of Sciences and Techniques Errachidia, Morocco; Corresponding author.Biochemistry of Natural Products Team, Faculty of Sciences and Techniques Errachidia, MoroccoFaculty of Medicine and Pharmacy, Fes, MoroccoBiochemistry of Natural Products Team, Faculty of Sciences and Techniques Errachidia, MoroccoLaboratory of Biotechnology and Sustainable Development of Natural Ressources, Polydisciplinary Faculty, Sultan Moulay Slimane University, Beni Mellal, MoroccoBiochemistry of Natural Products Team, Faculty of Sciences and Techniques Errachidia, MoroccoBiochemistry of Natural Products Team, Faculty of Sciences and Techniques Errachidia, MoroccoDate (Phoenix dactylifera L.) seeds are seen as good drug to cure rheumatoid arthritis and asthma in Moroccan traditional medicine. The present research aimed to study the anti-inflammatory effect, of methanol extract of different date seed varieties using membrane stabilizing effect, nitric oxide radical scavenging activity, inhibition of protein denaturation, carrageenan-induced paw edema and croton oil induced ear edema. The polyphenolic profile was examined using HPLC-DAD. Rutin, quercetin, p-coumaric and caffeic acids were the main among the analysed phenolic compounds. Concerning the anti-inflammatory activity, the analysed date seed were significantly effective in scavenging nitric oxide free radical, in stabilisation of erythrocyte membrane and possessed a high anti denaturation effect. In agreement with this finding, date seed exhibited a profound ability to reduce paw and ear swelling induced by carrageenan and croton oil respectively. The biochemical parameters showed that date seed are able to reduce the erythrocyte sedimentation rate (ERS) and C-reactive protein (CRP) concentration in rats used in Carrageenan-induced paw edema model. The predominant phenolic compounds are the potential candidates that drive these activities and the differences observed among varieties are related to their chemical composition. These data suggest that date seeds can be explored as a therapeutic agent for the treatment of inflammatory diseases.http://www.sciencedirect.com/science/article/pii/S2405844020302814ToxicologyInflammationNatural productPolyphenolOxidative stressAntioxidant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eimad dine Tariq Bouhlali Abdelbasset Hmidani Bouchra Bourkhis Tarik Khouya Mhamed Ramchoun Younes Filali-Zegzouti Chakib Alem |
spellingShingle |
Eimad dine Tariq Bouhlali Abdelbasset Hmidani Bouchra Bourkhis Tarik Khouya Mhamed Ramchoun Younes Filali-Zegzouti Chakib Alem Phenolic profile and anti-inflammatory activity of four Moroccan date (Phoenix dactylifera L.) seed varieties Heliyon Toxicology Inflammation Natural product Polyphenol Oxidative stress Antioxidant |
author_facet |
Eimad dine Tariq Bouhlali Abdelbasset Hmidani Bouchra Bourkhis Tarik Khouya Mhamed Ramchoun Younes Filali-Zegzouti Chakib Alem |
author_sort |
Eimad dine Tariq Bouhlali |
title |
Phenolic profile and anti-inflammatory activity of four Moroccan date (Phoenix dactylifera L.) seed varieties |
title_short |
Phenolic profile and anti-inflammatory activity of four Moroccan date (Phoenix dactylifera L.) seed varieties |
title_full |
Phenolic profile and anti-inflammatory activity of four Moroccan date (Phoenix dactylifera L.) seed varieties |
title_fullStr |
Phenolic profile and anti-inflammatory activity of four Moroccan date (Phoenix dactylifera L.) seed varieties |
title_full_unstemmed |
Phenolic profile and anti-inflammatory activity of four Moroccan date (Phoenix dactylifera L.) seed varieties |
title_sort |
phenolic profile and anti-inflammatory activity of four moroccan date (phoenix dactylifera l.) seed varieties |
publisher |
Elsevier |
series |
Heliyon |
issn |
2405-8440 |
publishDate |
2020-02-01 |
description |
Date (Phoenix dactylifera L.) seeds are seen as good drug to cure rheumatoid arthritis and asthma in Moroccan traditional medicine. The present research aimed to study the anti-inflammatory effect, of methanol extract of different date seed varieties using membrane stabilizing effect, nitric oxide radical scavenging activity, inhibition of protein denaturation, carrageenan-induced paw edema and croton oil induced ear edema. The polyphenolic profile was examined using HPLC-DAD. Rutin, quercetin, p-coumaric and caffeic acids were the main among the analysed phenolic compounds. Concerning the anti-inflammatory activity, the analysed date seed were significantly effective in scavenging nitric oxide free radical, in stabilisation of erythrocyte membrane and possessed a high anti denaturation effect. In agreement with this finding, date seed exhibited a profound ability to reduce paw and ear swelling induced by carrageenan and croton oil respectively. The biochemical parameters showed that date seed are able to reduce the erythrocyte sedimentation rate (ERS) and C-reactive protein (CRP) concentration in rats used in Carrageenan-induced paw edema model. The predominant phenolic compounds are the potential candidates that drive these activities and the differences observed among varieties are related to their chemical composition. These data suggest that date seeds can be explored as a therapeutic agent for the treatment of inflammatory diseases. |
topic |
Toxicology Inflammation Natural product Polyphenol Oxidative stress Antioxidant |
url |
http://www.sciencedirect.com/science/article/pii/S2405844020302814 |
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