A novel wound rinsing solution based on nano colloidal silver
Objective(s): The present study aimed to investigate the antiseptic properties of a colloidal nano silver wound rinsing solution to inhibit a wide range of pathogens including bacteria, viruses and fungus present in chronic and acute wounds. Materials and Methods:The wound rinsing solution named Sil...
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Mashhad University of Medical Sciences
2014-10-01
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doaj-3b9908d1513444b6a04d3c60310d140e2020-11-25T00:13:08ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042014-10-01153153233063A novel wound rinsing solution based on nano colloidal silverSoheila Kordestani0Farzaneh NayebHabib1Mohammad Hosein Saadatjo21Biomaterial Group, Medical Engineering Department, AmirKabir University of Technology, Tehran, Iran 2ChitoTech Company, Khaghani Building, Somayrh Avenue, Tehran, Iran1Biomaterial Group, Medical Engineering Department, AmirKabir University of Technology, Tehran, IranShahid Sadughi Medical University, Yazd, IranObjective(s): The present study aimed to investigate the antiseptic properties of a colloidal nano silver wound rinsing solution to inhibit a wide range of pathogens including bacteria, viruses and fungus present in chronic and acute wounds. Materials and Methods:The wound rinsing solution named SilvoSept® was prepared using colloidal nano silver suspension. Physicochemical properties, effectiveness against microorganism including Staphylocoocous aureus ATCC 6538P, Pseudomonas aeruginosa ATCC 9027, Escherichia coli ATCC 8739 ,Candida albicans ATCC 10231, Aspergillus niger ATCC 16404, MRSA , Mycobacterium spp. , HSV-1 and H1N1, and biocompatibility tests were carried out according to relevant standards . Results: X-ray diffraction (XRD) scan was performed on the sample and verify single phase of silver particles in the compound. The size of the silver particles in the solution, measured by dynamic light scattering (DLS) techniqu, ranged 80-90 nm. Transmission electron microscopy (TEM) revealed spherical shape with smooth surface of the silver nanoparticles. SilvoSept® reduced 5 log from the initial count of 107 CFU/mL of Staphylocoocous aureus ATCC 6538P, Pseudomonas aeruginosa ATCC 9027, Escherichia coli ATCC 8739, Candida albicans ATCC 10231, Aspergillus niger ATCC 16404, MRSA, Mycobacterium spp. Further assessments of SilvoSept solution exhibited a significant inhibition on the replication of HSV-1 and H1N1. The biocompatibility studies showed that the solution was non-allergic, non-irritant and noncytotoxic. Conclusion: Findings of the present study showed that SilvoSept® wound rinsing solution containing nano silver particles is an effective antiseptic solution against a wide spectrum of microorganism. This compound can be a suitable candidate for wound irrigation. http://nmj.mums.ac.ir/pdf_3063_8f772ead7b94b977ad3f65096c2811ae.htmlAntimicrobialNano silverSilvoSept® |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Soheila Kordestani Farzaneh NayebHabib Mohammad Hosein Saadatjo |
spellingShingle |
Soheila Kordestani Farzaneh NayebHabib Mohammad Hosein Saadatjo A novel wound rinsing solution based on nano colloidal silver Nanomedicine Journal Antimicrobial Nano silver SilvoSept® |
author_facet |
Soheila Kordestani Farzaneh NayebHabib Mohammad Hosein Saadatjo |
author_sort |
Soheila Kordestani |
title |
A novel wound rinsing solution based on nano colloidal silver |
title_short |
A novel wound rinsing solution based on nano colloidal silver |
title_full |
A novel wound rinsing solution based on nano colloidal silver |
title_fullStr |
A novel wound rinsing solution based on nano colloidal silver |
title_full_unstemmed |
A novel wound rinsing solution based on nano colloidal silver |
title_sort |
novel wound rinsing solution based on nano colloidal silver |
publisher |
Mashhad University of Medical Sciences |
series |
Nanomedicine Journal |
issn |
2322-3049 2322-5904 |
publishDate |
2014-10-01 |
description |
Objective(s): The present study aimed to investigate the antiseptic properties of a colloidal nano silver wound rinsing solution to inhibit a wide range of pathogens including bacteria, viruses and fungus present in chronic and acute wounds. Materials and Methods:The wound rinsing solution named SilvoSept® was prepared using colloidal nano silver suspension. Physicochemical properties, effectiveness against microorganism including Staphylocoocous aureus ATCC 6538P, Pseudomonas aeruginosa ATCC 9027, Escherichia coli ATCC 8739 ,Candida albicans ATCC 10231, Aspergillus niger ATCC 16404, MRSA , Mycobacterium spp. , HSV-1 and H1N1, and biocompatibility tests were carried out according to relevant standards . Results: X-ray diffraction (XRD) scan was performed on the sample and verify single phase of silver particles in the compound. The size of the silver particles in the solution, measured by dynamic light scattering (DLS) techniqu, ranged 80-90 nm. Transmission electron microscopy (TEM) revealed spherical shape with smooth surface of the silver nanoparticles. SilvoSept® reduced 5 log from the initial count of 107 CFU/mL of Staphylocoocous aureus ATCC 6538P, Pseudomonas aeruginosa ATCC 9027, Escherichia coli ATCC 8739, Candida albicans ATCC 10231, Aspergillus niger ATCC 16404, MRSA, Mycobacterium spp. Further assessments of SilvoSept solution exhibited a significant inhibition on the replication of HSV-1 and H1N1. The biocompatibility studies showed that the solution was non-allergic, non-irritant and noncytotoxic. Conclusion: Findings of the present study showed that SilvoSept® wound rinsing solution containing nano silver particles is an effective antiseptic solution against a wide spectrum of microorganism. This compound can be a suitable candidate for wound irrigation. |
topic |
Antimicrobial Nano silver SilvoSept® |
url |
http://nmj.mums.ac.ir/pdf_3063_8f772ead7b94b977ad3f65096c2811ae.html |
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