Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming

Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming

Recent studies have shown that defined factors could lead to the direct conversion of fibroblasts into induced hepatocyte-like cells (iHeps). However, reported conversion efficiencies are very low, and the underlying mechanism of the direct hepatic reprogramming is largely unknown. Here, we report t...

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Bibliographic Details
Main Authors: Kyung Tae Lim, Seung Chan Lee, Yimeng Gao, Kee-Pyo Kim, Guangqi Song, Su Yeon An, Kenjiro Adachi, Yu Jin Jang, Jonghun Kim, Kyoung-Jin Oh, Tae Hwan Kwak, Seon In Hwang, Jueng Soo You, Kinarm Ko, Seung-Hoi Koo, Amar Deep Sharma, Jong-Hoon Kim, Lijian Hui, Tobias Cantz, Hans R. Schöler, Dong Wook Han
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Cell Reports
Subjects:
direct conversion
induced hepatocytes
conversion kinetics
MET
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716303606

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