Clinical significance of endocan in Behçet’s disease patients: A potential marker of disease activity
Background: Endothelial cell dysfunction has been described in Behçet disease (BD) not only as a cause of major vascular events but also related to chronic inflammation in different organ systems. Aim of the work: To study the relation of serum endocan, a marker of endothelial dysfunction, with clin...
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doaj-3bb326e4e73245dc9ad7e035dc27692f2020-11-25T00:32:44ZengElsevierEgyptian Rheumatologist1110-11642019-01-014115964Clinical significance of endocan in Behçet’s disease patients: A potential marker of disease activityMarwa A. Hammad0Shaimaa M. Abdel-Latif1Omaima Z. Shehata2Amany M. Mohiey El-Din3Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt; Corresponding author.Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Sharkia, EgyptRheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Sharkia, EgyptClinical Pathology Department, Faculty of Medicine, Zagazig University, Sharkia, EgyptBackground: Endothelial cell dysfunction has been described in Behçet disease (BD) not only as a cause of major vascular events but also related to chronic inflammation in different organ systems. Aim of the work: To study the relation of serum endocan, a marker of endothelial dysfunction, with clinical manifestations and disease activity in BD patients. Patients and methods: This study included 23 BD patients and 23 matched controls. Disease activity was assessed by the Behcet Disease Current Activity Form (BDCAF). Serum endocan was measured in all subjects. Results: The mean age of the patients was 32.5 ± 6.8 years and they were 16 males and 7 females (M:F 2.3:1) with mean disease duration of 7 ± 5.2 years. Their mean BDCAF was 2.26 ± 1.32. A significant difference was found between serum endocan level among active patients 328.24 ± 195.3 ng/L, inactive patients (169.8 ± 35.7 ng/L) and controls (160.6 ± 39.7 ng/L)(p = 0.001). Patients with genital ulcers, papulopastular lesions and arthritis at the time of the study had higher serum endocan level than those without (p = 0.002, p = 0.006 and p = 0.0001 respectively). Serum endocan levels correlated significantly with the BDCAF, neutrophil/lymphocyte ratio, platelet lymphocyte ratio and C-reactive protein (r = 0.94, p = 0.0001; r = 0.82, p = 0.0001, r = 0.44, p = 0.04 and r = 0.48, p = 0.02 respectively). The optimum serum endocan cut-off point for active BD was 191.5 ng/L with a sensitivity and specificity of 100% and 86% respectively (area under curve 0.99, 95% confidence interval 0.96-1). Conclusion: Serum endocan may serve as a potential marker of disease activity in BD. Patients with genital ulcers, papulopastular lesions and arthritis showed higher serum endocan levels. Keywords: Endocan, Behçet’s disease, Endothelial dysfunction, BDCAFhttp://www.sciencedirect.com/science/article/pii/S1110116418300589 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marwa A. Hammad Shaimaa M. Abdel-Latif Omaima Z. Shehata Amany M. Mohiey El-Din |
spellingShingle |
Marwa A. Hammad Shaimaa M. Abdel-Latif Omaima Z. Shehata Amany M. Mohiey El-Din Clinical significance of endocan in Behçet’s disease patients: A potential marker of disease activity Egyptian Rheumatologist |
author_facet |
Marwa A. Hammad Shaimaa M. Abdel-Latif Omaima Z. Shehata Amany M. Mohiey El-Din |
author_sort |
Marwa A. Hammad |
title |
Clinical significance of endocan in Behçet’s disease patients: A potential marker of disease activity |
title_short |
Clinical significance of endocan in Behçet’s disease patients: A potential marker of disease activity |
title_full |
Clinical significance of endocan in Behçet’s disease patients: A potential marker of disease activity |
title_fullStr |
Clinical significance of endocan in Behçet’s disease patients: A potential marker of disease activity |
title_full_unstemmed |
Clinical significance of endocan in Behçet’s disease patients: A potential marker of disease activity |
title_sort |
clinical significance of endocan in behçet’s disease patients: a potential marker of disease activity |
publisher |
Elsevier |
series |
Egyptian Rheumatologist |
issn |
1110-1164 |
publishDate |
2019-01-01 |
description |
Background: Endothelial cell dysfunction has been described in Behçet disease (BD) not only as a cause of major vascular events but also related to chronic inflammation in different organ systems. Aim of the work: To study the relation of serum endocan, a marker of endothelial dysfunction, with clinical manifestations and disease activity in BD patients. Patients and methods: This study included 23 BD patients and 23 matched controls. Disease activity was assessed by the Behcet Disease Current Activity Form (BDCAF). Serum endocan was measured in all subjects. Results: The mean age of the patients was 32.5 ± 6.8 years and they were 16 males and 7 females (M:F 2.3:1) with mean disease duration of 7 ± 5.2 years. Their mean BDCAF was 2.26 ± 1.32. A significant difference was found between serum endocan level among active patients 328.24 ± 195.3 ng/L, inactive patients (169.8 ± 35.7 ng/L) and controls (160.6 ± 39.7 ng/L)(p = 0.001). Patients with genital ulcers, papulopastular lesions and arthritis at the time of the study had higher serum endocan level than those without (p = 0.002, p = 0.006 and p = 0.0001 respectively). Serum endocan levels correlated significantly with the BDCAF, neutrophil/lymphocyte ratio, platelet lymphocyte ratio and C-reactive protein (r = 0.94, p = 0.0001; r = 0.82, p = 0.0001, r = 0.44, p = 0.04 and r = 0.48, p = 0.02 respectively). The optimum serum endocan cut-off point for active BD was 191.5 ng/L with a sensitivity and specificity of 100% and 86% respectively (area under curve 0.99, 95% confidence interval 0.96-1). Conclusion: Serum endocan may serve as a potential marker of disease activity in BD. Patients with genital ulcers, papulopastular lesions and arthritis showed higher serum endocan levels. Keywords: Endocan, Behçet’s disease, Endothelial dysfunction, BDCAF |
url |
http://www.sciencedirect.com/science/article/pii/S1110116418300589 |
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