Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients
Hong-Yun Zhao,1,* Guo-Wei Ma,1,* Ben-Yan Zou,1,* Mei Li,1 Su-Xia Lin,1 Li-Ping Zhao,2 Ying Guo,1 Yan Huang,1 Ying Tian,1 Dan Xie,1 Li Zhang1 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People...
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2014-07-01
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doaj-3bb61d99eaa74d528f72468749efad382020-11-25T01:18:36ZengDove Medical PressOncoTargets and Therapy1178-69302014-07-012014default1301131017630Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patientsZhao HYMa GWZou BYLi MLin SXZhao LPGuo YHuang YTian YXie DZhang L Hong-Yun Zhao,1,* Guo-Wei Ma,1,* Ben-Yan Zou,1,* Mei Li,1 Su-Xia Lin,1 Li-Ping Zhao,2 Ying Guo,1 Yan Huang,1 Ying Tian,1 Dan Xie,1 Li Zhang1 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 2Department of Medical Oncology, Zhongshan Hospital of Sun Yat-Sen University, Zhongshan People’s City Hospital, Zhongshan, People’s Republic of China *The first three authors contributed equally to this work Abstract: The aim of the present study was to investigate the clinicopathologic/prognostic significance of thymidylate synthase (TS), orotate phosphoribosyltransferase (OPRT), and thymidine phosphorylase (TP) proteins in postoperative non-small cell lung cancer (NSCLC) patients. Microarray slides from a set of 178 NSCLC patients were used for the detection of TS, OPRT, and TP expression by immunohistochemistry. The correlation between clinicopathologic factors and protein expression of three proteins was analyzed. Ninety seven carcinomas (57.4%) were TS-positive, 90 carcinomas (53.9%) were OPRT-positive, and 102 carcinomas (69.4%) were TP-positive. Compared with the TS-positive patients, the overall survival (OS) was significantly lower in the TS-negative patients (hazard ratio [HR] =1.766, 95% confidence interval [CI] =1.212–2.573, P=0.003). Significant differences between TS-positive and TS-negative patients was also observed in the following stratified analyses: 1) adenocarcinoma subgroup (HR =2.079, 95% CI =1.235–3.500, P=0.006); 2) less than 60-year-old subgroup (HR =1.890, 95% CI =1.061–3.366, P=0.031); 3) stage II/III subgroup (HR =1.594, 95% CI =1.036–2.453, P=0.034); and 4) surgery plus adjuvant therapy subgroup (HR =1.976, 95% CI =1.226–3.185, P=0.005). However, the OS was not significantly correlated with OPRT or TP protein expression. This study demonstrates that the TS level in tumor tissues may be a useful marker to predict the postoperative OS in NSCLC patients. Keywords: orotate phosphoribosyltransferase, thymidine phosphorylasehttp://www.dovepress.com/prognostic-significance-of-thymidylate-synthase-in-postoperative-non-s-peer-reviewed-article-OTT |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhao HY Ma GW Zou BY Li M Lin SX Zhao LP Guo Y Huang Y Tian Y Xie D Zhang L |
spellingShingle |
Zhao HY Ma GW Zou BY Li M Lin SX Zhao LP Guo Y Huang Y Tian Y Xie D Zhang L Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients OncoTargets and Therapy |
author_facet |
Zhao HY Ma GW Zou BY Li M Lin SX Zhao LP Guo Y Huang Y Tian Y Xie D Zhang L |
author_sort |
Zhao HY |
title |
Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients |
title_short |
Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients |
title_full |
Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients |
title_fullStr |
Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients |
title_full_unstemmed |
Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients |
title_sort |
prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2014-07-01 |
description |
Hong-Yun Zhao,1,* Guo-Wei Ma,1,* Ben-Yan Zou,1,* Mei Li,1 Su-Xia Lin,1 Li-Ping Zhao,2 Ying Guo,1 Yan Huang,1 Ying Tian,1 Dan Xie,1 Li Zhang1 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 2Department of Medical Oncology, Zhongshan Hospital of Sun Yat-Sen University, Zhongshan People’s City Hospital, Zhongshan, People’s Republic of China *The first three authors contributed equally to this work Abstract: The aim of the present study was to investigate the clinicopathologic/prognostic significance of thymidylate synthase (TS), orotate phosphoribosyltransferase (OPRT), and thymidine phosphorylase (TP) proteins in postoperative non-small cell lung cancer (NSCLC) patients. Microarray slides from a set of 178 NSCLC patients were used for the detection of TS, OPRT, and TP expression by immunohistochemistry. The correlation between clinicopathologic factors and protein expression of three proteins was analyzed. Ninety seven carcinomas (57.4%) were TS-positive, 90 carcinomas (53.9%) were OPRT-positive, and 102 carcinomas (69.4%) were TP-positive. Compared with the TS-positive patients, the overall survival (OS) was significantly lower in the TS-negative patients (hazard ratio [HR] =1.766, 95% confidence interval [CI] =1.212–2.573, P=0.003). Significant differences between TS-positive and TS-negative patients was also observed in the following stratified analyses: 1) adenocarcinoma subgroup (HR =2.079, 95% CI =1.235–3.500, P=0.006); 2) less than 60-year-old subgroup (HR =1.890, 95% CI =1.061–3.366, P=0.031); 3) stage II/III subgroup (HR =1.594, 95% CI =1.036–2.453, P=0.034); and 4) surgery plus adjuvant therapy subgroup (HR =1.976, 95% CI =1.226–3.185, P=0.005). However, the OS was not significantly correlated with OPRT or TP protein expression. This study demonstrates that the TS level in tumor tissues may be a useful marker to predict the postoperative OS in NSCLC patients. Keywords: orotate phosphoribosyltransferase, thymidine phosphorylase |
url |
http://www.dovepress.com/prognostic-significance-of-thymidylate-synthase-in-postoperative-non-s-peer-reviewed-article-OTT |
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