Effect of laparoscopic splenectomy on portal vein thrombosis and serum YKL-40 in patients with cirrhotic portal hypertension
Introduction and objectives: Laparoscopic splenectomy (LS) is a supportive intervention for cirrhotic patients. However, its efficacy for patients with cirrhotic portal hypertension (CPH) still needs clarification. Studies indicated YKL-40 might be effective targets for treatment of splenomegaly, ho...
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2019-11-01
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doaj-3bc1342f03534caf8c0b4614335079c82021-06-09T05:56:26ZengElsevierAnnals of Hepatology1665-26812019-11-01186898901Effect of laparoscopic splenectomy on portal vein thrombosis and serum YKL-40 in patients with cirrhotic portal hypertensionRuizhao Qi0Xin Jin1Haida Shi2Chengfang Wang3Huixing Li4Xianjie Shi5Department of General Surgery, 5th Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Hepatobilliary Surgery, 4th Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Hepatobilliary Surgery, 4th Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Hepatobilliary Surgery, Chinese PLA General Hospital, Beijing, ChinaDepartment of General Surgery, Aerospace Center Hospital, Beijing, ChinaDepartment of Hepatobilliary Surgery, Chinese PLA General Hospital, Beijing, China; Corresponding author.Introduction and objectives: Laparoscopic splenectomy (LS) is a supportive intervention for cirrhotic patients. However, its efficacy for patients with cirrhotic portal hypertension (CPH) still needs clarification. Studies indicated YKL-40 might be effective targets for treatment of splenomegaly, however deeper insights are unclear. The aim of this study was to investigate the effect of LS on the formation of portal vein thrombosis (PVT) and serum levels of a fibrosis marker, YKL-40, in patients with CPH. Materials and methods: A total of 80 patients who underwent LS and 30 healthy controls were investigated in this study. Serum levels of YKL-40 were measured by enzyme-linked immunosorbent assay (ELISA). Demographic characteristics including age and gender were recorded. Clinicopathological and laboratory examinations included the severity of esophageal varices and the presence of viral hepatitis. The liver function was assessed according to the Child–Pugh classification. The incidence of PVT before and after operation was also monitored. Results: Serum YKL-40 was significantly increased in CPH patients, and was associated with Child–Pugh score and HBV infection. Furthermore, elderly patients had an increased risk for postoperative PVT. Higher serum YKL-40 was observed in patients with thrombus at postoperative 7, 14 and 21 days than those without thrombus. Conclusions: LS could reduce serum YKL-40 levels and PVT progression and was a useful treatment for patients <40 years of age with CPH.http://www.sciencedirect.com/science/article/pii/S1665268119321969Cirrhotic portal hypertensionLaparoscopic splenectomyPortal vein thrombosisYKL-40 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruizhao Qi Xin Jin Haida Shi Chengfang Wang Huixing Li Xianjie Shi |
spellingShingle |
Ruizhao Qi Xin Jin Haida Shi Chengfang Wang Huixing Li Xianjie Shi Effect of laparoscopic splenectomy on portal vein thrombosis and serum YKL-40 in patients with cirrhotic portal hypertension Annals of Hepatology Cirrhotic portal hypertension Laparoscopic splenectomy Portal vein thrombosis YKL-40 |
author_facet |
Ruizhao Qi Xin Jin Haida Shi Chengfang Wang Huixing Li Xianjie Shi |
author_sort |
Ruizhao Qi |
title |
Effect of laparoscopic splenectomy on portal vein thrombosis and serum YKL-40 in patients with cirrhotic portal hypertension |
title_short |
Effect of laparoscopic splenectomy on portal vein thrombosis and serum YKL-40 in patients with cirrhotic portal hypertension |
title_full |
Effect of laparoscopic splenectomy on portal vein thrombosis and serum YKL-40 in patients with cirrhotic portal hypertension |
title_fullStr |
Effect of laparoscopic splenectomy on portal vein thrombosis and serum YKL-40 in patients with cirrhotic portal hypertension |
title_full_unstemmed |
Effect of laparoscopic splenectomy on portal vein thrombosis and serum YKL-40 in patients with cirrhotic portal hypertension |
title_sort |
effect of laparoscopic splenectomy on portal vein thrombosis and serum ykl-40 in patients with cirrhotic portal hypertension |
publisher |
Elsevier |
series |
Annals of Hepatology |
issn |
1665-2681 |
publishDate |
2019-11-01 |
description |
Introduction and objectives: Laparoscopic splenectomy (LS) is a supportive intervention for cirrhotic patients. However, its efficacy for patients with cirrhotic portal hypertension (CPH) still needs clarification. Studies indicated YKL-40 might be effective targets for treatment of splenomegaly, however deeper insights are unclear. The aim of this study was to investigate the effect of LS on the formation of portal vein thrombosis (PVT) and serum levels of a fibrosis marker, YKL-40, in patients with CPH. Materials and methods: A total of 80 patients who underwent LS and 30 healthy controls were investigated in this study. Serum levels of YKL-40 were measured by enzyme-linked immunosorbent assay (ELISA). Demographic characteristics including age and gender were recorded. Clinicopathological and laboratory examinations included the severity of esophageal varices and the presence of viral hepatitis. The liver function was assessed according to the Child–Pugh classification. The incidence of PVT before and after operation was also monitored. Results: Serum YKL-40 was significantly increased in CPH patients, and was associated with Child–Pugh score and HBV infection. Furthermore, elderly patients had an increased risk for postoperative PVT. Higher serum YKL-40 was observed in patients with thrombus at postoperative 7, 14 and 21 days than those without thrombus. Conclusions: LS could reduce serum YKL-40 levels and PVT progression and was a useful treatment for patients <40 years of age with CPH. |
topic |
Cirrhotic portal hypertension Laparoscopic splenectomy Portal vein thrombosis YKL-40 |
url |
http://www.sciencedirect.com/science/article/pii/S1665268119321969 |
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