Therapeutic Bispecific T-Cell Engager Antibody Targeting the Transferrin Receptor

Therapeutic Bispecific T-Cell Engager Antibody Targeting the Transferrin Receptor

Bispecific T-cell engager antibodies (BiTE) have been explored as a means to recruit cytolytic T cells to kill tumor cells. The transferrin receptor (TfR) is highly expressed on the surface of rapidly proliferating tumor cells. Therefore, it holds great potential in T cell redirecting therapies. In...

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Bibliographic Details
Main Authors: Mingpeng Fu, Qi He, Zilong Guo, Xiaoran Zhou, Heli Li, Liang Zhao, Hongling Tang, Xiaoqi Zhou, Huifen Zhu, Guanxin Shen, Yong He, Ping Lei
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
bispecific antibodies
T-cell engager
transferrin receptor
tumor immunotherapy
solid tumor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01396/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01396/full

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