| Summary: | QUESTION: There is no doubt that the most significant advances made back in 2018 in interventional cardiology were the long-awaited results from clinical trials with MitraClip (Abbott Laboratories, Abbott Park, Illinois, USA): the MITRA-FR (Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation) presented at the congress organized by the European Society of Cardiology, and the COAPT (Cardiovascular Outcomes Assessment of the Mitra- Clip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation) presented at the Transcatheter Cardiovascular Therapeutics (TCT) congress. Both trials have been discussed extensively. Could you please tell us what the basic differences are in the results obtained by these 2 trials? RESPUESTA: That’s right, both trials have put the spotlight on mitral regurgitation (MR) as the therapeutic target in patients with heart failure and reduced ejection fraction (HF-REF). The COAPT trial randomized 614 patients with HF-REF (left ventricular ejection fraction between 20% and 50%) and moderate-to-severe HF treated with the optimal medical therapy in order to follow 2 therapeutic strategies (1:1): a) optimal medical therapy, or b) optimal medical therapy plus percutaneous implant of MitraClip.1.After 2 years there was a 47% reduction in the risk of the primary endpoint of efficacy (hospitalizations due to heart failure) in the intervention group. Similarly, there was a significant drop in allcause mortality (hazard ratio, 0.62;...
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