Variants of intensification of immunosuppressive therapy of rheumatoid arthritis
Objective. To assess influence of different treatment intensification regimens on clinico- laboratory parameters of activity and quality of life of pts with rheumatoid arthritis (RA). Material and methods. 40 RA pts of group 1 received pulse-therapy with methotrexate (MT) and dexamethasone (DM), 20p...
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doaj-3bdd11cb6674464eaaffa9df1becb2272021-08-02T09:05:38ZrusIMA-PRESS LLCНаучно-практическая ревматология1995-44841995-44922007-04-01452303510.14412/1995-4484-2007-835908Variants of intensification of immunosuppressive therapy of rheumatoid arthritisE A VasiljevaA L MaslyanskyE P IlivanovaA L GrigorjevaV M TrishinV I MasurovObjective. To assess influence of different treatment intensification regimens on clinico- laboratory parameters of activity and quality of life of pts with rheumatoid arthritis (RA). Material and methods. 40 RA pts of group 1 received pulse-therapy with methotrexate (MT) and dexamethasone (DM), 20ptsofgroup 2 received pulse-therapy with methylprednisolone (MP) and cyclophosphane (CP). After that all pts continued treatment with disease modifying antirheumatic drugs. Pts were examined at baseline, 1 and 6 months after completion of therapy intensification cycle. Results. At 1 month tender and swollen joint counts decrease in group 1 was more prominent than in group 2. After 6 months significant decrease of all disease activity measures was maintained in group 1 but not in pts received CP and MP. Conclusion. Pulse therapy with MT and DM provided more prolonged decrease of RA clinico-laboratory activity than treatment with MP and CP. Group 1 pts also showed significant increase of quality of life. None method of intensive treatment caused severe adverse events.https://rsp.mediar-press.net/rsp/article/view/968rheumatoid arthritismethylprednisolonedexamethasonecyclophosphanemethotrexatetherapy intensification |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
E A Vasiljeva A L Maslyansky E P Ilivanova A L Grigorjeva V M Trishin V I Masurov |
spellingShingle |
E A Vasiljeva A L Maslyansky E P Ilivanova A L Grigorjeva V M Trishin V I Masurov Variants of intensification of immunosuppressive therapy of rheumatoid arthritis Научно-практическая ревматология rheumatoid arthritis methylprednisolone dexamethasone cyclophosphane methotrexate therapy intensification |
author_facet |
E A Vasiljeva A L Maslyansky E P Ilivanova A L Grigorjeva V M Trishin V I Masurov |
author_sort |
E A Vasiljeva |
title |
Variants of intensification of immunosuppressive therapy of rheumatoid arthritis |
title_short |
Variants of intensification of immunosuppressive therapy of rheumatoid arthritis |
title_full |
Variants of intensification of immunosuppressive therapy of rheumatoid arthritis |
title_fullStr |
Variants of intensification of immunosuppressive therapy of rheumatoid arthritis |
title_full_unstemmed |
Variants of intensification of immunosuppressive therapy of rheumatoid arthritis |
title_sort |
variants of intensification of immunosuppressive therapy of rheumatoid arthritis |
publisher |
IMA-PRESS LLC |
series |
Научно-практическая ревматология |
issn |
1995-4484 1995-4492 |
publishDate |
2007-04-01 |
description |
Objective. To assess influence of different treatment intensification regimens on clinico- laboratory parameters of activity and quality of life of pts with rheumatoid arthritis (RA). Material and methods. 40 RA pts of group 1 received pulse-therapy with methotrexate (MT) and dexamethasone (DM), 20ptsofgroup 2 received pulse-therapy with methylprednisolone (MP) and cyclophosphane (CP). After that all pts continued treatment with disease modifying antirheumatic drugs. Pts were examined at baseline, 1 and 6 months after completion of therapy intensification cycle. Results. At 1 month tender and swollen joint counts decrease in group 1 was more prominent than in group 2. After 6 months significant decrease of all disease activity measures was maintained in group 1 but not in pts received CP and MP. Conclusion. Pulse therapy with MT and DM provided more prolonged decrease of RA clinico-laboratory activity than treatment with MP and CP. Group 1 pts also showed significant increase of quality of life. None method of intensive treatment caused severe adverse events. |
topic |
rheumatoid arthritis methylprednisolone dexamethasone cyclophosphane methotrexate therapy intensification |
url |
https://rsp.mediar-press.net/rsp/article/view/968 |
work_keys_str_mv |
AT eavasiljeva variantsofintensificationofimmunosuppressivetherapyofrheumatoidarthritis AT almaslyansky variantsofintensificationofimmunosuppressivetherapyofrheumatoidarthritis AT epilivanova variantsofintensificationofimmunosuppressivetherapyofrheumatoidarthritis AT algrigorjeva variantsofintensificationofimmunosuppressivetherapyofrheumatoidarthritis AT vmtrishin variantsofintensificationofimmunosuppressivetherapyofrheumatoidarthritis AT vimasurov variantsofintensificationofimmunosuppressivetherapyofrheumatoidarthritis |
_version_ |
1721236057490456576 |