STUDY REGARDING THE ASSOCIATION BETWEEN CHRONIC PERIODONTITIS AND THE PREVALENCE OF HEAD-NECK CARCINOMA
Background and aim Substantial evidence supports an association between chronic infections/inflammation, and cancer. The aim of this study was to assess the effect of chronic periodontitis on head and neck squamouscell carcinoma (HNSCC). Material and methods The study population consisted of 46 pa...
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doaj-3bdd12cc1661467da8ae17f63c5778c02020-11-24T20:42:30ZengRomanian Society of Oral RehabilitationRomanian Journal of Oral Rehabilitation2066-70002601-46612015-04-0171101106STUDY REGARDING THE ASSOCIATION BETWEEN CHRONIC PERIODONTITIS AND THE PREVALENCE OF HEAD-NECK CARCINOMADiana-Cristala Nițescu0Cristian Mârţu1Sorina Solomon2Irina Ursărescu3Ioana Mârțu4Lucian Burlea5 Silvia Mârțu16“Grigore T. Popa" University of Medicine and Pharmacy - Iași, Romania, Faculty of Dental Medicine, Department of Periodontology“Grigore T. Popa" University of Medicine and Pharmacy - Iași, Romania, Faculty of Dental Medicine, ENT Department, Clinical Rehabilitation Hospital Iasi, Romania“Grigore T. Popa" University of Medicine and Pharmacy - Iași, Romania, Faculty of Dental Medicine, Department of Periodontology“Grigore T. Popa" University of Medicine and Pharmacy - Iași, Romania, Faculty of Dental Medicine, Department of Periodontology“Grigore T. Popa" University of Medicine and Pharmacy - Iași, Romania, Faculty of Dental Medicine, Department of Periodontology“Grigore T. Popa" University of Medicine and Pharmacy - Iași, Romania, Faculty of Dental Medicine, Department of Periodontology“Grigore T. Popa" University of Medicine and Pharmacy - Iași, Romania, Faculty of Dental Medicine, Department of PeriodontologyBackground and aim Substantial evidence supports an association between chronic infections/inflammation, and cancer. The aim of this study was to assess the effect of chronic periodontitis on head and neck squamouscell carcinoma (HNSCC). Material and methods The study population consisted of 46 patients, divided into two groups. Cases were patients diagnosed with primary HNSCC (n=26). Controls were all patients seen during the same period of time but negative for malignancy (n=20). The severity of periodontitis was assessed through clinical determination of the bleeding index, periodontal index, tooth mobility degree and alveolar bone loss (ABL) on standardized panoramic radiographs. Results and discussions: Each millimeter of ABL was associated with >4-fold increased risk of HNSCC. The strength of the association was greatest in the oral cavity, followed by the oropharynx and larynx. The association persisted in subjects who never used tobacco and alcohol. Patients with periodontitis, whose bleeding and periodontal indices and tooth mobility values were higher, were more likely to have poorly differentiated oral cavity SCC than those without periodontitis (32.8% versus 11.5%; P = 0.038). Conclusions This study suggests that chronic periodontitis is a risk factor for HNSCC. These results have implications for practical and improved strategies for prevention, diagnosis, and treatment of HNSCC. http://www.rjor.ro/study-regarding-the-association-between-chronic-periodontitis-and-the-prevalence-of-head-neck-carcinoma/?lang=roalveolar bone lossbleeding indexchronic periodontitishead and neck carcinomaperiodontal indextooth mobility |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Diana-Cristala Nițescu Cristian Mârţu Sorina Solomon Irina Ursărescu Ioana Mârțu Lucian Burlea Silvia Mârțu1 |
spellingShingle |
Diana-Cristala Nițescu Cristian Mârţu Sorina Solomon Irina Ursărescu Ioana Mârțu Lucian Burlea Silvia Mârțu1 STUDY REGARDING THE ASSOCIATION BETWEEN CHRONIC PERIODONTITIS AND THE PREVALENCE OF HEAD-NECK CARCINOMA Romanian Journal of Oral Rehabilitation alveolar bone loss bleeding index chronic periodontitis head and neck carcinoma periodontal index tooth mobility |
author_facet |
Diana-Cristala Nițescu Cristian Mârţu Sorina Solomon Irina Ursărescu Ioana Mârțu Lucian Burlea Silvia Mârțu1 |
author_sort |
Diana-Cristala Nițescu |
title |
STUDY REGARDING THE ASSOCIATION BETWEEN CHRONIC PERIODONTITIS AND THE PREVALENCE OF HEAD-NECK CARCINOMA |
title_short |
STUDY REGARDING THE ASSOCIATION BETWEEN CHRONIC PERIODONTITIS AND THE PREVALENCE OF HEAD-NECK CARCINOMA |
title_full |
STUDY REGARDING THE ASSOCIATION BETWEEN CHRONIC PERIODONTITIS AND THE PREVALENCE OF HEAD-NECK CARCINOMA |
title_fullStr |
STUDY REGARDING THE ASSOCIATION BETWEEN CHRONIC PERIODONTITIS AND THE PREVALENCE OF HEAD-NECK CARCINOMA |
title_full_unstemmed |
STUDY REGARDING THE ASSOCIATION BETWEEN CHRONIC PERIODONTITIS AND THE PREVALENCE OF HEAD-NECK CARCINOMA |
title_sort |
study regarding the association between chronic periodontitis and the prevalence of head-neck carcinoma |
publisher |
Romanian Society of Oral Rehabilitation |
series |
Romanian Journal of Oral Rehabilitation |
issn |
2066-7000 2601-4661 |
publishDate |
2015-04-01 |
description |
Background and aim Substantial evidence supports an association between chronic infections/inflammation,
and cancer. The aim of this study was to assess the effect of chronic periodontitis on head and neck squamouscell
carcinoma (HNSCC). Material and methods The study population consisted of 46 patients, divided into
two groups. Cases were patients diagnosed with primary HNSCC (n=26). Controls were all patients seen during
the same period of time but negative for malignancy (n=20). The severity of periodontitis was assessed through
clinical determination of the bleeding index, periodontal index, tooth mobility degree and alveolar bone loss
(ABL) on standardized panoramic radiographs. Results and discussions: Each millimeter of ABL was
associated with >4-fold increased risk of HNSCC. The strength of the association was greatest in the oral cavity,
followed by the oropharynx and larynx. The association persisted in subjects who never used tobacco and
alcohol. Patients with periodontitis, whose bleeding and periodontal indices and tooth mobility values were
higher, were more likely to have poorly differentiated oral cavity SCC than those without periodontitis (32.8%
versus 11.5%; P = 0.038). Conclusions This study suggests that chronic periodontitis is a risk factor for
HNSCC. These results have implications for practical and improved strategies for prevention, diagnosis, and
treatment of HNSCC.
|
topic |
alveolar bone loss bleeding index chronic periodontitis head and neck carcinoma periodontal index tooth mobility |
url |
http://www.rjor.ro/study-regarding-the-association-between-chronic-periodontitis-and-the-prevalence-of-head-neck-carcinoma/?lang=ro |
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