Human lacrimal gland regeneration: Perspectives and review of literature
The human lacrimal gland is an essential component of the lacrimal functional unit (LFU). Any perturbation of this unit can lead to the debilitating morbid condition called the dry eye syndrome (DES). The current line of therapy available for dry eye remains supportive and palliative with the patien...
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doaj-3be3593083574d5294147d450cb91d2e2021-04-02T21:04:40ZengWolters Kluwer Medknow PublicationsSaudi Journal of Ophthalmology1319-45342014-01-012811218Human lacrimal gland regeneration: Perspectives and review of literatureShubha Tiwari, M.Pharm0Mohammad Javed Ali, MS, FRCS1Geeta K. Vemuganti, MS, FNAMS2Sudhakar and Sreekant Ravi Stem Cell Biology Laboratory, L. V. Prasad Eye Institute, Hyderabad, IndiaDacryology Service, L. V. Prasad Eye Institute, Hyderabad, IndiaSudhakar and Sreekant Ravi Stem Cell Biology Laboratory, L. V. Prasad Eye Institute, Hyderabad, India; School of Medical Sciences, University of Hyderabad, Hyderabad, India; Corresponding author at: School of Medical Sciences, University of Hyderabad, Hyderabad, India. Tel.: +91 4030612345.The human lacrimal gland is an essential component of the lacrimal functional unit (LFU). Any perturbation of this unit can lead to the debilitating morbid condition called the dry eye syndrome (DES). The current line of therapy available for dry eye remains supportive and palliative with the patient being dependent on life long and frequent administration of lubricating eye drops. Even advanced therapies like punctual plugs, cyclosporine B administration, and salivary gland auto-transplantation have led to a limited success. Under these scenarios, the option of cell based therapy needs to be explored to provide better and long term relief to these patients. This review gives an overview of the efforts in lacrimal gland regeneration and examines the past and ongoing research in cell based therapies in animals as well as human lacrimal gland cultures. The authors discuss their first of its kind functionally viable human lacrimal gland in vitro culture system from fresh exenteration specimens. A brief overview of research in near future and the potential implications of lacrimal gland regenerative therapies have been discussed. Keywords: Lacrimal gland, Regeneration, Dry eye, Stem cellshttp://www.sciencedirect.com/science/article/pii/S1319453413001033 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shubha Tiwari, M.Pharm Mohammad Javed Ali, MS, FRCS Geeta K. Vemuganti, MS, FNAMS |
spellingShingle |
Shubha Tiwari, M.Pharm Mohammad Javed Ali, MS, FRCS Geeta K. Vemuganti, MS, FNAMS Human lacrimal gland regeneration: Perspectives and review of literature Saudi Journal of Ophthalmology |
author_facet |
Shubha Tiwari, M.Pharm Mohammad Javed Ali, MS, FRCS Geeta K. Vemuganti, MS, FNAMS |
author_sort |
Shubha Tiwari, M.Pharm |
title |
Human lacrimal gland regeneration: Perspectives and review of literature |
title_short |
Human lacrimal gland regeneration: Perspectives and review of literature |
title_full |
Human lacrimal gland regeneration: Perspectives and review of literature |
title_fullStr |
Human lacrimal gland regeneration: Perspectives and review of literature |
title_full_unstemmed |
Human lacrimal gland regeneration: Perspectives and review of literature |
title_sort |
human lacrimal gland regeneration: perspectives and review of literature |
publisher |
Wolters Kluwer Medknow Publications |
series |
Saudi Journal of Ophthalmology |
issn |
1319-4534 |
publishDate |
2014-01-01 |
description |
The human lacrimal gland is an essential component of the lacrimal functional unit (LFU). Any perturbation of this unit can lead to the debilitating morbid condition called the dry eye syndrome (DES). The current line of therapy available for dry eye remains supportive and palliative with the patient being dependent on life long and frequent administration of lubricating eye drops. Even advanced therapies like punctual plugs, cyclosporine B administration, and salivary gland auto-transplantation have led to a limited success. Under these scenarios, the option of cell based therapy needs to be explored to provide better and long term relief to these patients. This review gives an overview of the efforts in lacrimal gland regeneration and examines the past and ongoing research in cell based therapies in animals as well as human lacrimal gland cultures. The authors discuss their first of its kind functionally viable human lacrimal gland in vitro culture system from fresh exenteration specimens. A brief overview of research in near future and the potential implications of lacrimal gland regenerative therapies have been discussed. Keywords: Lacrimal gland, Regeneration, Dry eye, Stem cells |
url |
http://www.sciencedirect.com/science/article/pii/S1319453413001033 |
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