12<i>N</i>-Substituted Matrinol Derivatives Inhibited the Expression of Fibrogenic Genes via Repressing Integrin/FAK/PI3K/Akt Pathway in Hepatic Stellate Cells

12<i>N</i>-Substituted Matrinol Derivatives Inhibited the Expression of Fibrogenic Genes via Repressing Integrin/FAK/PI3K/Akt Pathway in Hepatic Stellate Cells

Twenty new 12<i>N</i>-substituted matrinol derivatives were synthesized and evaluated for their inhibitory effects on collagen &#945;1 (I) (COL1A1) promotor in human hepatic stellate LX-2 cells. The structure-activity relationship (SAR) revealed that introducing a 12<i>N</i&...

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Bibliographic Details
Main Authors: Yunyang Bao, Yudong Pang, Sheng Tang, Tianyun Niu, Zhihao Guo, Hongwei He, Yinghong Li, Danqing Song
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molecules
Subjects:
liver fibrosis
matrinol
structure−activity relationship
col1a1
integrin/fak pathway
Online Access:https://www.mdpi.com/1420-3049/24/20/3748

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