Anti-Tumor Drug-Loaded Oxygen Nanobubbles for the Degradation of HIF-1α and the Upregulation of Reactive Oxygen Species in Tumor Cells

Anti-Tumor Drug-Loaded Oxygen Nanobubbles for the Degradation of HIF-1α and the Upregulation of Reactive Oxygen Species in Tumor Cells

Hypoxia is a key concern during the treatment of tumors, and hypoxia-inducible factor 1 alpha (HIF-1α) has been associated with increased tumor resistance to therapeutic modalities. In this study, doxorubicin-loaded oxygen nanobubbles (Dox/ONBs) were synthesized, and the effectiveness of dr...

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Bibliographic Details
Main Authors: Muhammad Saad Khan, Jangsun Hwang, Kyungwoo Lee, Yonghyun Choi, Youngmin Seo, Hojeong Jeon, Jong Wook Hong, Jonghoon Choi
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
doxorubicin
drug delivery
oxygen nanobubbles
hypoxia
hypoxia-inducible factor 1 alpha
Online Access:https://www.mdpi.com/2072-6694/11/10/1464

Internet

https://www.mdpi.com/2072-6694/11/10/1464

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