Effects of Transcranial Stimulation With Direct and Alternating Current on Resting-State Functional Connectivity: An Exploratory Study Simultaneously Combining Stimulation and Multiband Functional Magnetic Resonance Imaging
Background: Transcranial stimulation with direct (tDCS) and alternating current (tACS) has increasingly gained interest in various fields, from cognitive neuroscience to clinical investigations. Transcranial current stimulation used alone may modulate brain activity that consequently influences beha...
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doaj-3bfa84b9774f488ca54b0b150e985c4d2020-11-25T03:52:19ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612020-02-011310.3389/fnhum.2019.00474484350Effects of Transcranial Stimulation With Direct and Alternating Current on Resting-State Functional Connectivity: An Exploratory Study Simultaneously Combining Stimulation and Multiband Functional Magnetic Resonance ImagingMarine Mondino0Sukhmanjit Ghumman1Claire Gane2Emmanuelle Renauld3Kevin Whittingstall4Shirley Fecteau5Department of Psychiatry and Neurosciences, Medical School, Université Laval, CERVO Brain Research Center, Centre Intégré Universitaire en Santé et Services Sociaux de la Capitale-Nationale, Quebec City, QC, CanadaDepartment of Radiology, Faculty of Medicine and Health Science, University of Sherbrooke, Sherbrooke, QC, CanadaDepartment of Psychiatry and Neurosciences, Medical School, Université Laval, CERVO Brain Research Center, Centre Intégré Universitaire en Santé et Services Sociaux de la Capitale-Nationale, Quebec City, QC, CanadaDepartment of Psychiatry and Neurosciences, Medical School, Université Laval, CERVO Brain Research Center, Centre Intégré Universitaire en Santé et Services Sociaux de la Capitale-Nationale, Quebec City, QC, CanadaDepartment of Radiology, Faculty of Medicine and Health Science, University of Sherbrooke, Sherbrooke, QC, CanadaDepartment of Psychiatry and Neurosciences, Medical School, Université Laval, CERVO Brain Research Center, Centre Intégré Universitaire en Santé et Services Sociaux de la Capitale-Nationale, Quebec City, QC, CanadaBackground: Transcranial stimulation with direct (tDCS) and alternating current (tACS) has increasingly gained interest in various fields, from cognitive neuroscience to clinical investigations. Transcranial current stimulation used alone may modulate brain activity that consequently influences behaviors, without providing information on potentially induced brain activity changes. The combination of transcranial current stimulation and functional magnetic resonance imaging (fMRI) may help to address this. This exploratory study investigated instantaneous and subsequent effects of tDCS and tACS on resting-state functional connectivity (rsFC) in healthy adults.Methods: We conducted a randomized crossover study with 15 healthy subjects receiving three stimulation conditions (tDCS, tACS, and sham) on separate days. Stimulation was applied over the left and right dorsolateral prefrontal cortex (DLPFC) for 30 min (1 mA). rsFC of the targeted prefrontal areas was assessed before, during, and after stimulation using multiband fMRI and using left and right DLPFC as seeds.Results: Both tDCS and tACS increased rsFC during and after the stimulation period, as compared to sham. tDCS-induced changes were observed between the left DLPFC and bilateral parietal regions at the junction of the superior parietal and the inferior parietal lobules. tACS-induced changes were observed between the left DLPFC and the right inferior parietal lobule.Conclusion: Overall, these results suggest that a single session with a low dose, 1 mA, of tDCS or tACS can cause changes in fronto-parietal connectivity that occur rapidly, that is, within the first 15 min. Although exploratory, this work contributes to the discussion of the potential of transcranial current stimulation to modulate resting-state networks and the interest of combining transcranial current stimulation with neuroimaging to identify these changes.https://www.frontiersin.org/article/10.3389/fnhum.2019.00474/fulltDCS–transcranial direct current stimulationtACS (transcranial alternating current stimulation)fMRI–functional magnetic resonance imagingfunctional connectivityfronto-parietal connectivity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marine Mondino Sukhmanjit Ghumman Claire Gane Emmanuelle Renauld Kevin Whittingstall Shirley Fecteau |
spellingShingle |
Marine Mondino Sukhmanjit Ghumman Claire Gane Emmanuelle Renauld Kevin Whittingstall Shirley Fecteau Effects of Transcranial Stimulation With Direct and Alternating Current on Resting-State Functional Connectivity: An Exploratory Study Simultaneously Combining Stimulation and Multiband Functional Magnetic Resonance Imaging Frontiers in Human Neuroscience tDCS–transcranial direct current stimulation tACS (transcranial alternating current stimulation) fMRI–functional magnetic resonance imaging functional connectivity fronto-parietal connectivity |
author_facet |
Marine Mondino Sukhmanjit Ghumman Claire Gane Emmanuelle Renauld Kevin Whittingstall Shirley Fecteau |
author_sort |
Marine Mondino |
title |
Effects of Transcranial Stimulation With Direct and Alternating Current on Resting-State Functional Connectivity: An Exploratory Study Simultaneously Combining Stimulation and Multiband Functional Magnetic Resonance Imaging |
title_short |
Effects of Transcranial Stimulation With Direct and Alternating Current on Resting-State Functional Connectivity: An Exploratory Study Simultaneously Combining Stimulation and Multiband Functional Magnetic Resonance Imaging |
title_full |
Effects of Transcranial Stimulation With Direct and Alternating Current on Resting-State Functional Connectivity: An Exploratory Study Simultaneously Combining Stimulation and Multiband Functional Magnetic Resonance Imaging |
title_fullStr |
Effects of Transcranial Stimulation With Direct and Alternating Current on Resting-State Functional Connectivity: An Exploratory Study Simultaneously Combining Stimulation and Multiband Functional Magnetic Resonance Imaging |
title_full_unstemmed |
Effects of Transcranial Stimulation With Direct and Alternating Current on Resting-State Functional Connectivity: An Exploratory Study Simultaneously Combining Stimulation and Multiband Functional Magnetic Resonance Imaging |
title_sort |
effects of transcranial stimulation with direct and alternating current on resting-state functional connectivity: an exploratory study simultaneously combining stimulation and multiband functional magnetic resonance imaging |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2020-02-01 |
description |
Background: Transcranial stimulation with direct (tDCS) and alternating current (tACS) has increasingly gained interest in various fields, from cognitive neuroscience to clinical investigations. Transcranial current stimulation used alone may modulate brain activity that consequently influences behaviors, without providing information on potentially induced brain activity changes. The combination of transcranial current stimulation and functional magnetic resonance imaging (fMRI) may help to address this. This exploratory study investigated instantaneous and subsequent effects of tDCS and tACS on resting-state functional connectivity (rsFC) in healthy adults.Methods: We conducted a randomized crossover study with 15 healthy subjects receiving three stimulation conditions (tDCS, tACS, and sham) on separate days. Stimulation was applied over the left and right dorsolateral prefrontal cortex (DLPFC) for 30 min (1 mA). rsFC of the targeted prefrontal areas was assessed before, during, and after stimulation using multiband fMRI and using left and right DLPFC as seeds.Results: Both tDCS and tACS increased rsFC during and after the stimulation period, as compared to sham. tDCS-induced changes were observed between the left DLPFC and bilateral parietal regions at the junction of the superior parietal and the inferior parietal lobules. tACS-induced changes were observed between the left DLPFC and the right inferior parietal lobule.Conclusion: Overall, these results suggest that a single session with a low dose, 1 mA, of tDCS or tACS can cause changes in fronto-parietal connectivity that occur rapidly, that is, within the first 15 min. Although exploratory, this work contributes to the discussion of the potential of transcranial current stimulation to modulate resting-state networks and the interest of combining transcranial current stimulation with neuroimaging to identify these changes. |
topic |
tDCS–transcranial direct current stimulation tACS (transcranial alternating current stimulation) fMRI–functional magnetic resonance imaging functional connectivity fronto-parietal connectivity |
url |
https://www.frontiersin.org/article/10.3389/fnhum.2019.00474/full |
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