Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life?
There is some evidence that maternal smoking increases susceptibility to personal smoking's detrimental effects. One might question whether early life disadvantage might influence susceptibility to occupational exposure.In this cross-sectional study we investigated respiratory symptoms, asthma...
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doaj-3bff8b2d643a4bf3a6bba9fc54b0641c2020-11-25T01:18:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01107e013195910.1371/journal.pone.0131959Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life?Øistein SvanesTrude Duelien SkorgeAne JohannessenRandi Jacobsen BertelsenMagne BråtveitBertil ForsbergThorarin GislasonMathias HolmChrister JansonRain JögiFerenc MacsaliDan NorbäckErnst Reidar OmenaasFrancisco Gómez RealVivi SchlünssenTorben SigsgaardGunilla WieslanderJan-Paul ZockTor AasenJulia DratvaCecilie SvanesThere is some evidence that maternal smoking increases susceptibility to personal smoking's detrimental effects. One might question whether early life disadvantage might influence susceptibility to occupational exposure.In this cross-sectional study we investigated respiratory symptoms, asthma and self-reported chronic obstructive pulmonary disease (COPD) as related to working as a cleaner in Northern European populations, and whether early life factors influenced susceptibility to occupational cleaning's unhealthy effects.The RHINE III questionnaire study assessed occupational cleaning in 13,499 participants. Associations with respiratory symptoms, asthma and self-reported COPD were analysed with multiple logistic regressions, adjusting for sex, age, smoking, educational level, parent´s educational level, BMI and participating centre. Interaction of occupational cleaning with early life disadvantage (maternal smoking, severe respiratory infection <5 years, born during winter months, maternal age at birth >35 years) was investigated.Among 2138 ever-cleaners the risks of wheeze (OR 1.4, 95% CI 1.3-1.6), adult-onset asthma (1.5 [1.2-1.8]) and self-reported COPD (1.7 [1.3-2.2]) were increased. The risk increased with years in occupational cleaning (adult-onset asthma: ≤1 year 0.9 [0.7-1.3]; 1-4 years 1.5 [1.1-2.0]; ≥4 years 1.6 [1.2-2.1]). The association of wheeze with cleaning activity ≥4 years was significantly stronger for those with early life disadvantage than in those without (1.8 [1.5-2.3] vs. 1.3 [0.96-1.8]; pinteraction 0.035).Occupational cleaners had increased risk of asthma and self-reported COPD. Respiratory symptom risk was particularly increased in persons with factors suggestive of early life disadvantage. We hypothesize that early life disadvantage may increase airway vulnerability to harmful exposure from cleaning agents later in life.http://europepmc.org/articles/PMC4500550?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Øistein Svanes Trude Duelien Skorge Ane Johannessen Randi Jacobsen Bertelsen Magne Bråtveit Bertil Forsberg Thorarin Gislason Mathias Holm Christer Janson Rain Jögi Ferenc Macsali Dan Norbäck Ernst Reidar Omenaas Francisco Gómez Real Vivi Schlünssen Torben Sigsgaard Gunilla Wieslander Jan-Paul Zock Tor Aasen Julia Dratva Cecilie Svanes |
spellingShingle |
Øistein Svanes Trude Duelien Skorge Ane Johannessen Randi Jacobsen Bertelsen Magne Bråtveit Bertil Forsberg Thorarin Gislason Mathias Holm Christer Janson Rain Jögi Ferenc Macsali Dan Norbäck Ernst Reidar Omenaas Francisco Gómez Real Vivi Schlünssen Torben Sigsgaard Gunilla Wieslander Jan-Paul Zock Tor Aasen Julia Dratva Cecilie Svanes Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life? PLoS ONE |
author_facet |
Øistein Svanes Trude Duelien Skorge Ane Johannessen Randi Jacobsen Bertelsen Magne Bråtveit Bertil Forsberg Thorarin Gislason Mathias Holm Christer Janson Rain Jögi Ferenc Macsali Dan Norbäck Ernst Reidar Omenaas Francisco Gómez Real Vivi Schlünssen Torben Sigsgaard Gunilla Wieslander Jan-Paul Zock Tor Aasen Julia Dratva Cecilie Svanes |
author_sort |
Øistein Svanes |
title |
Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life? |
title_short |
Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life? |
title_full |
Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life? |
title_fullStr |
Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life? |
title_full_unstemmed |
Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life? |
title_sort |
respiratory health in cleaners in northern europe: is susceptibility established in early life? |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
There is some evidence that maternal smoking increases susceptibility to personal smoking's detrimental effects. One might question whether early life disadvantage might influence susceptibility to occupational exposure.In this cross-sectional study we investigated respiratory symptoms, asthma and self-reported chronic obstructive pulmonary disease (COPD) as related to working as a cleaner in Northern European populations, and whether early life factors influenced susceptibility to occupational cleaning's unhealthy effects.The RHINE III questionnaire study assessed occupational cleaning in 13,499 participants. Associations with respiratory symptoms, asthma and self-reported COPD were analysed with multiple logistic regressions, adjusting for sex, age, smoking, educational level, parent´s educational level, BMI and participating centre. Interaction of occupational cleaning with early life disadvantage (maternal smoking, severe respiratory infection <5 years, born during winter months, maternal age at birth >35 years) was investigated.Among 2138 ever-cleaners the risks of wheeze (OR 1.4, 95% CI 1.3-1.6), adult-onset asthma (1.5 [1.2-1.8]) and self-reported COPD (1.7 [1.3-2.2]) were increased. The risk increased with years in occupational cleaning (adult-onset asthma: ≤1 year 0.9 [0.7-1.3]; 1-4 years 1.5 [1.1-2.0]; ≥4 years 1.6 [1.2-2.1]). The association of wheeze with cleaning activity ≥4 years was significantly stronger for those with early life disadvantage than in those without (1.8 [1.5-2.3] vs. 1.3 [0.96-1.8]; pinteraction 0.035).Occupational cleaners had increased risk of asthma and self-reported COPD. Respiratory symptom risk was particularly increased in persons with factors suggestive of early life disadvantage. We hypothesize that early life disadvantage may increase airway vulnerability to harmful exposure from cleaning agents later in life. |
url |
http://europepmc.org/articles/PMC4500550?pdf=render |
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