Central Systolic Blood Pressure Is Associated With Early Vascular Damage in Children and Adolescents With Type 1 Diabetes
Objective of the study: This study aimed to test the effect of multiple cardiovascular risk factors on subclinical indices of atherosclerosis in children and adolescents with type 1 diabetes (T1D).Methods: Carotid intima-media thickness (cIMT), carotid distensibility coefficient (cDC), and carotid–f...
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doaj-3c11964d070449918368125b3afe5cd92021-09-07T04:33:26ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-09-01810.3389/fcvm.2021.606103606103Central Systolic Blood Pressure Is Associated With Early Vascular Damage in Children and Adolescents With Type 1 DiabetesAngela Tagetti0Claudia A. Piona1Denise Marcon2Alice Giontella3Lorella Branz4Stefano Bortolotti5Anita Morandi6Claudio Maffeis7Cristiano Fava8Department of Medicine, General Medicine and Hypertension Unit, University of Verona, Verona, ItalyPediatric Diabetes and Metabolic Disorders Unit, Regional Center for Pediatric Diabetes, University City Hospital of Verona, Verona, ItalyDepartment of Medicine, General Medicine and Hypertension Unit, University of Verona, Verona, ItalyDepartment of Medicine, General Medicine and Hypertension Unit, University of Verona, Verona, ItalyDepartment of Medicine, General Medicine and Hypertension Unit, University of Verona, Verona, ItalyDepartment of Medicine, General Medicine and Hypertension Unit, University of Verona, Verona, ItalyPediatric Diabetes and Metabolic Disorders Unit, Regional Center for Pediatric Diabetes, University City Hospital of Verona, Verona, ItalyPediatric Diabetes and Metabolic Disorders Unit, Regional Center for Pediatric Diabetes, University City Hospital of Verona, Verona, ItalyDepartment of Medicine, General Medicine and Hypertension Unit, University of Verona, Verona, ItalyObjective of the study: This study aimed to test the effect of multiple cardiovascular risk factors on subclinical indices of atherosclerosis in children and adolescents with type 1 diabetes (T1D).Methods: Carotid intima-media thickness (cIMT), carotid distensibility coefficient (cDC), and carotid–femoral pulse wave velocity (PWV) were measured in children and adolescents with T1D, in a follow-up at the outpatient clinics of Verona. Blood pressure (BP; both central and peripheral), metabolic and other cardiovascular risk factors were evaluated in multivariate linear regressions to assess the association with the measured indices of subclinical vascular damage.Results: One hundred and twenty-six children and adolescents were included. cIMT was above the 95th percentile for age and height in 60.8% of the population, whereas 26% of the sample had cDC impairment (less than the 5th percentile) and 4.8% had an elevated PWV. Independent determinants of cIMT according to the regression models were only gender type of glucose monitoring and central systolic BP (cSBP). PWV was associated with age, sex, heart rate, and cSBP; cDC with age and both cSBP and, alternatively, peripheral BP (pBP). Neither pBP nor any of the tested metabolic parameters, including glycated hemoglobin, was associated with PWV and cIMT.Conclusions: A high proportion of early vascular damage, especially an increased cIMT, is present in children and adolescents with T1D in whom cSBP seems to be a common determinant. In children and adolescents with T1DM, a special focus should be on hemodynamic risk factors beyond metabolic ones.https://www.frontiersin.org/articles/10.3389/fcvm.2021.606103/fulladolescentcarotid intima-media thicknessarterial pressurechildrisk factorstype 1 diabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Angela Tagetti Claudia A. Piona Denise Marcon Alice Giontella Lorella Branz Stefano Bortolotti Anita Morandi Claudio Maffeis Cristiano Fava |
spellingShingle |
Angela Tagetti Claudia A. Piona Denise Marcon Alice Giontella Lorella Branz Stefano Bortolotti Anita Morandi Claudio Maffeis Cristiano Fava Central Systolic Blood Pressure Is Associated With Early Vascular Damage in Children and Adolescents With Type 1 Diabetes Frontiers in Cardiovascular Medicine adolescent carotid intima-media thickness arterial pressure child risk factors type 1 diabetes |
author_facet |
Angela Tagetti Claudia A. Piona Denise Marcon Alice Giontella Lorella Branz Stefano Bortolotti Anita Morandi Claudio Maffeis Cristiano Fava |
author_sort |
Angela Tagetti |
title |
Central Systolic Blood Pressure Is Associated With Early Vascular Damage in Children and Adolescents With Type 1 Diabetes |
title_short |
Central Systolic Blood Pressure Is Associated With Early Vascular Damage in Children and Adolescents With Type 1 Diabetes |
title_full |
Central Systolic Blood Pressure Is Associated With Early Vascular Damage in Children and Adolescents With Type 1 Diabetes |
title_fullStr |
Central Systolic Blood Pressure Is Associated With Early Vascular Damage in Children and Adolescents With Type 1 Diabetes |
title_full_unstemmed |
Central Systolic Blood Pressure Is Associated With Early Vascular Damage in Children and Adolescents With Type 1 Diabetes |
title_sort |
central systolic blood pressure is associated with early vascular damage in children and adolescents with type 1 diabetes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2021-09-01 |
description |
Objective of the study: This study aimed to test the effect of multiple cardiovascular risk factors on subclinical indices of atherosclerosis in children and adolescents with type 1 diabetes (T1D).Methods: Carotid intima-media thickness (cIMT), carotid distensibility coefficient (cDC), and carotid–femoral pulse wave velocity (PWV) were measured in children and adolescents with T1D, in a follow-up at the outpatient clinics of Verona. Blood pressure (BP; both central and peripheral), metabolic and other cardiovascular risk factors were evaluated in multivariate linear regressions to assess the association with the measured indices of subclinical vascular damage.Results: One hundred and twenty-six children and adolescents were included. cIMT was above the 95th percentile for age and height in 60.8% of the population, whereas 26% of the sample had cDC impairment (less than the 5th percentile) and 4.8% had an elevated PWV. Independent determinants of cIMT according to the regression models were only gender type of glucose monitoring and central systolic BP (cSBP). PWV was associated with age, sex, heart rate, and cSBP; cDC with age and both cSBP and, alternatively, peripheral BP (pBP). Neither pBP nor any of the tested metabolic parameters, including glycated hemoglobin, was associated with PWV and cIMT.Conclusions: A high proportion of early vascular damage, especially an increased cIMT, is present in children and adolescents with T1D in whom cSBP seems to be a common determinant. In children and adolescents with T1DM, a special focus should be on hemodynamic risk factors beyond metabolic ones. |
topic |
adolescent carotid intima-media thickness arterial pressure child risk factors type 1 diabetes |
url |
https://www.frontiersin.org/articles/10.3389/fcvm.2021.606103/full |
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