Primary Malignant Melanoma of the Breast: A Report of Two Cases
Primary malignant melanoma of the breast (PMMB) is a rare tumor with only a few case reports available in the literature. We report two cases of PMMB, one derived from the breast parenchyma and the other from the breast skin. The first case consisted of atypical epithelioid cells without overt melan...
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Korean Society of Pathologists & the Korean Society for Cytopathology
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doaj-3c16ea7cdf024d72b05557f5a12d6ab72020-11-24T23:59:28ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452019-03-0153211912410.4132/jptm.2018.10.1816808Primary Malignant Melanoma of the Breast: A Report of Two CasesJiwon Koh0Jihyeon Lee1So Youn Jung2Han Sung Kang3Tak Yun4Youngmee Kwon5 Department of Pathology, Seoul National University College of Medicine, Seoul, Korea Department of Pathology, National Cancer Center, Goyang, Korea Center for Breast Cancer, National Cancer Center, Goyang, Korea Center for Breast Cancer, National Cancer Center, Goyang, Korea Center for Specific Organs Center, National Cancer Center, Goyang, Korea Department of Pathology, National Cancer Center, Goyang, KoreaPrimary malignant melanoma of the breast (PMMB) is a rare tumor with only a few case reports available in the literature. We report two cases of PMMB, one derived from the breast parenchyma and the other from the breast skin. The first case consisted of atypical epithelioid cells without overt melanocytic differentiation like melanin pigments. The tumor cells showed diffuse positivity for S100 protein, tyrosinase, and BRAF V600E. However, the tumor cells were negative for cytokeratin, epithelial membrane antigen, and HMB-45. The second case showed atypical melanocytic proliferation with heavy melanin pigmentation. The tumor cells were positive for S100 protein, HMB-45, tyrosinase, and BRAF V600E. These two cases represent two distinct presentations of PMMB in terms of skin involvement, melanin pigmentation, and HMB-45 positivity. Although PMMB is very rare, the possibility of this entity should be considered in malignant epithelioid neoplasms in the breast parenchyma.http://www.jpatholtm.org/upload/pdf/jptm-2018-10-18.pdfBreastMalignant melanoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiwon Koh Jihyeon Lee So Youn Jung Han Sung Kang Tak Yun Youngmee Kwon |
spellingShingle |
Jiwon Koh Jihyeon Lee So Youn Jung Han Sung Kang Tak Yun Youngmee Kwon Primary Malignant Melanoma of the Breast: A Report of Two Cases Journal of Pathology and Translational Medicine Breast Malignant melanoma |
author_facet |
Jiwon Koh Jihyeon Lee So Youn Jung Han Sung Kang Tak Yun Youngmee Kwon |
author_sort |
Jiwon Koh |
title |
Primary Malignant Melanoma of the Breast: A Report of Two Cases |
title_short |
Primary Malignant Melanoma of the Breast: A Report of Two Cases |
title_full |
Primary Malignant Melanoma of the Breast: A Report of Two Cases |
title_fullStr |
Primary Malignant Melanoma of the Breast: A Report of Two Cases |
title_full_unstemmed |
Primary Malignant Melanoma of the Breast: A Report of Two Cases |
title_sort |
primary malignant melanoma of the breast: a report of two cases |
publisher |
Korean Society of Pathologists & the Korean Society for Cytopathology |
series |
Journal of Pathology and Translational Medicine |
issn |
2383-7837 2383-7845 |
publishDate |
2019-03-01 |
description |
Primary malignant melanoma of the breast (PMMB) is a rare tumor with only a few case reports available in the literature. We report two cases of PMMB, one derived from the breast parenchyma and the other from the breast skin. The first case consisted of atypical epithelioid cells without overt melanocytic differentiation like melanin pigments. The tumor cells showed diffuse positivity for S100 protein, tyrosinase, and BRAF V600E. However, the tumor cells were negative for cytokeratin, epithelial membrane antigen, and HMB-45. The second case showed atypical melanocytic proliferation with heavy melanin pigmentation. The tumor cells were positive for S100 protein, HMB-45, tyrosinase, and BRAF V600E. These two cases represent two distinct presentations of PMMB in terms of skin involvement, melanin pigmentation, and HMB-45 positivity. Although PMMB is very rare, the possibility of this entity should be considered in malignant epithelioid neoplasms in the breast parenchyma. |
topic |
Breast Malignant melanoma |
url |
http://www.jpatholtm.org/upload/pdf/jptm-2018-10-18.pdf |
work_keys_str_mv |
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1725447976829059072 |