Predict Colon Cancer by Pairing Plasma miRNAs: Establishment of a Normalizer-Free, Cross-Platform Model

Predict Colon Cancer by Pairing Plasma miRNAs: Establishment of a Normalizer-Free, Cross-Platform Model

BackgroundPlasma miRNAs are emerging biomarkers for colon cancer (CC) diagnosis. However, the lack of robust internal references largely limits their clinical application. Here we propose a ratio-based, normalizer-free algorithm to quantitate plasma miRNA for CC diagnosis.MethodsA miRNA-pair matrix...

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Bibliographic Details
Main Authors: Da Qin, Qingdong Guo, Rui Wei, Si Liu, Shengtao Zhu, Shutian Zhang, Li Min
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
colon adenocarcinoma
miRNA
circulation miRNA
miRNA-pair
miRNA standardization
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.561763/full

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