PSMA-Targeting Positron Emission Agents for Imaging Solid Tumors Other Than Non-Prostate Carcinoma: A Systematic Review
Despite its name, prostate-specific membrane antigen (PSMA) has been shown using immunohistochemistry (IHC) to also be over-expressed in the tumor neovasculature of a wide variety of solid tumors other than prostate carcinoma. Accordingly, positron-emitting radiolabeled small molecules targeting PSM...
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doaj-3c1f4591273943a0a696c9a81ecae4462020-11-25T02:09:26ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-10-012019488610.3390/ijms20194886ijms20194886PSMA-Targeting Positron Emission Agents for Imaging Solid Tumors Other Than Non-Prostate Carcinoma: A Systematic ReviewChristophe Van de Wiele0Mike Sathekge1Bart de Spiegeleer2Pieter Jan de Jonghe3Laurence Beels4Alex Maes5Department of Nuclear Medicine, AZ Groeninge, 8500 Kortrijk, BelgiumDepartment of Nuclear Medicine, University of Pretoria, 0001 Pretoria, South-AfricaLaboratory of Drug Quality and Registration, University Ghent, 9000 Ghent, BelgiumDepartment of Nuclear Medicine, AZ Groeninge, 8500 Kortrijk, BelgiumDepartment of Nuclear Medicine, AZ Groeninge, 8500 Kortrijk, BelgiumDepartment of Nuclear Medicine, AZ Groeninge, 8500 Kortrijk, BelgiumDespite its name, prostate-specific membrane antigen (PSMA) has been shown using immunohistochemistry (IHC) to also be over-expressed in the tumor neovasculature of a wide variety of solid tumors other than prostate carcinoma. Accordingly, positron-emitting radiolabeled small molecules targeting PSMA, initially developed for positron emission tomography in prostate carcinomas, are currently being explored for their staging and restaging potential as an alternative imaging modality in other solid tumor types where 18-F-fluorodeoxyglucose (FDG)-PET imaging has low diagnostic accuracy. In this paper, the currently available literature in this field is reviewed. Preliminary, mainly retrospective studies are encouraging, with evidence of improved diagnostic sensitivity and specificity in clear cell renal carcinoma, glioma, and hepatocellular carcinoma, leading to a change in patient management in several patients. However, the results published thus far warrant confirmation by larger prospective studies additionally assessing the longitudinal impact on patient outcomes.https://www.mdpi.com/1422-0067/20/19/4886psmapositron emission tomography (pet)non prostate carcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christophe Van de Wiele Mike Sathekge Bart de Spiegeleer Pieter Jan de Jonghe Laurence Beels Alex Maes |
spellingShingle |
Christophe Van de Wiele Mike Sathekge Bart de Spiegeleer Pieter Jan de Jonghe Laurence Beels Alex Maes PSMA-Targeting Positron Emission Agents for Imaging Solid Tumors Other Than Non-Prostate Carcinoma: A Systematic Review International Journal of Molecular Sciences psma positron emission tomography (pet) non prostate carcinoma |
author_facet |
Christophe Van de Wiele Mike Sathekge Bart de Spiegeleer Pieter Jan de Jonghe Laurence Beels Alex Maes |
author_sort |
Christophe Van de Wiele |
title |
PSMA-Targeting Positron Emission Agents for Imaging Solid Tumors Other Than Non-Prostate Carcinoma: A Systematic Review |
title_short |
PSMA-Targeting Positron Emission Agents for Imaging Solid Tumors Other Than Non-Prostate Carcinoma: A Systematic Review |
title_full |
PSMA-Targeting Positron Emission Agents for Imaging Solid Tumors Other Than Non-Prostate Carcinoma: A Systematic Review |
title_fullStr |
PSMA-Targeting Positron Emission Agents for Imaging Solid Tumors Other Than Non-Prostate Carcinoma: A Systematic Review |
title_full_unstemmed |
PSMA-Targeting Positron Emission Agents for Imaging Solid Tumors Other Than Non-Prostate Carcinoma: A Systematic Review |
title_sort |
psma-targeting positron emission agents for imaging solid tumors other than non-prostate carcinoma: a systematic review |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-10-01 |
description |
Despite its name, prostate-specific membrane antigen (PSMA) has been shown using immunohistochemistry (IHC) to also be over-expressed in the tumor neovasculature of a wide variety of solid tumors other than prostate carcinoma. Accordingly, positron-emitting radiolabeled small molecules targeting PSMA, initially developed for positron emission tomography in prostate carcinomas, are currently being explored for their staging and restaging potential as an alternative imaging modality in other solid tumor types where 18-F-fluorodeoxyglucose (FDG)-PET imaging has low diagnostic accuracy. In this paper, the currently available literature in this field is reviewed. Preliminary, mainly retrospective studies are encouraging, with evidence of improved diagnostic sensitivity and specificity in clear cell renal carcinoma, glioma, and hepatocellular carcinoma, leading to a change in patient management in several patients. However, the results published thus far warrant confirmation by larger prospective studies additionally assessing the longitudinal impact on patient outcomes. |
topic |
psma positron emission tomography (pet) non prostate carcinoma |
url |
https://www.mdpi.com/1422-0067/20/19/4886 |
work_keys_str_mv |
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