Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection
Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp. In this paper, we report on the detection and identification of a new DSP toxin, th...
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doaj-3c23861f6fba44509ced88f0ef5868532020-11-24T22:43:17ZengMDPI AGMarine Drugs1660-33972008-08-0163489495Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry DetectionJosé J. FernándezManuel NorteJosé M. FrancoPatricia G. CruzAntonio H. DaranasBeatriz PazOkadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp. In this paper, we report on the detection and identification of a new DSP toxin, the OA isomer 19-epi-okadaic acid (2) (19-epi-OA), isolated from cultures of Prorocentrum belizeanum, by determining its retention time (RT) and fragmentation pattern using liquid chromatography coupled with mass spectrometry (LC–MS/MS).http://www.mdpi.com/1660-3397/6/3/489/Marine toxinsDSP19-epi-okadaic acidProrocentrum belizeanumLC-MS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
José J. Fernández Manuel Norte José M. Franco Patricia G. Cruz Antonio H. Daranas Beatriz Paz |
spellingShingle |
José J. Fernández Manuel Norte José M. Franco Patricia G. Cruz Antonio H. Daranas Beatriz Paz Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection Marine Drugs Marine toxins DSP 19-epi-okadaic acid Prorocentrum belizeanum LC-MS |
author_facet |
José J. Fernández Manuel Norte José M. Franco Patricia G. Cruz Antonio H. Daranas Beatriz Paz |
author_sort |
José J. Fernández |
title |
Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection |
title_short |
Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection |
title_full |
Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection |
title_fullStr |
Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection |
title_full_unstemmed |
Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection |
title_sort |
identification of 19-epi-okadaic acid, a new diarrhetic shellfish poisoning toxin, by liquid chromatography with mass spectrometry detection |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2008-08-01 |
description |
Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp. In this paper, we report on the detection and identification of a new DSP toxin, the OA isomer 19-epi-okadaic acid (2) (19-epi-OA), isolated from cultures of Prorocentrum belizeanum, by determining its retention time (RT) and fragmentation pattern using liquid chromatography coupled with mass spectrometry (LC–MS/MS). |
topic |
Marine toxins DSP 19-epi-okadaic acid Prorocentrum belizeanum LC-MS |
url |
http://www.mdpi.com/1660-3397/6/3/489/ |
work_keys_str_mv |
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