The N-Glycosylation of Mouse Immunoglobulin G (IgG)-Fragment Crystallizable Differs Between IgG Subclasses and Strains

The N-Glycosylation of Mouse Immunoglobulin G (IgG)-Fragment Crystallizable Differs Between IgG Subclasses and Strains

N-linked glycosylation of the fragment crystallizable (Fc)-region of immunoglobulin G (IgG) is known to have a large influence on the activity of the antibody, an effect reported to be IgG subclass specific. This situation applies both to humans and mice. The mouse is often used as experimental anim...

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Bibliographic Details
Main Authors: Noortje de Haan, Karli R. Reiding, Jasminka Krištić, Agnes L. Hipgrave Ederveen, Gordan Lauc, Manfred Wuhrer
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
mouse
immunoglobulin G
Fc-glycosylation
N-glycans
glycopeptides
LC-MS
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00608/full

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