TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis

Aberrant and persistent activation of the transcription factor STAT3 has been found in various types of cancers. Here the authors identify TRIM27 as a positive regulator of IL-6-induced STAT3 activation through the formation of JAK1-STAT3 complex, thus impacting inflammation-induced colon cancer dev...

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Main Authors:	Hong-Xia Zhang, Zhi-Sheng Xu, Hen Lin, Mi Li, Tian Xia, Kaisa Cui, Su-Yun Wang, Youjun Li, Hong-Bing Shu, Yan-Yi Wang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05796-z

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spelling	doaj-3c2d0b0fc6204a1b837bc243ca4ab4382021-05-11T10:08:59ZengNature Publishing GroupNature Communications2041-17232018-08-019111610.1038/s41467-018-05796-zTRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesisHong-Xia Zhang0Zhi-Sheng Xu1Hen Lin2Mi Li3Tian Xia4Kaisa Cui5Su-Yun Wang6Youjun Li7Hong-Bing Shu8Yan-Yi Wang9College of Life Sciences, Wuhan UniversityThe Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Childrenʼs Medical CenterCollege of Life Sciences, Wuhan UniversityCollege of Life Sciences, Wuhan UniversityCollege of Life Sciences, Wuhan UniversityCollege of Life Sciences, Wuhan UniversityWuhan Institute of Virology, Chinese Academy of SciencesCollege of Life Sciences, Wuhan UniversityCollege of Life Sciences, Wuhan UniversityWuhan Institute of Virology, Chinese Academy of SciencesAberrant and persistent activation of the transcription factor STAT3 has been found in various types of cancers. Here the authors identify TRIM27 as a positive regulator of IL-6-induced STAT3 activation through the formation of JAK1-STAT3 complex, thus impacting inflammation-induced colon cancer development.https://doi.org/10.1038/s41467-018-05796-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hong-Xia Zhang Zhi-Sheng Xu Hen Lin Mi Li Tian Xia Kaisa Cui Su-Yun Wang Youjun Li Hong-Bing Shu Yan-Yi Wang
spellingShingle	Hong-Xia Zhang Zhi-Sheng Xu Hen Lin Mi Li Tian Xia Kaisa Cui Su-Yun Wang Youjun Li Hong-Bing Shu Yan-Yi Wang TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis Nature Communications
author_facet	Hong-Xia Zhang Zhi-Sheng Xu Hen Lin Mi Li Tian Xia Kaisa Cui Su-Yun Wang Youjun Li Hong-Bing Shu Yan-Yi Wang
author_sort	Hong-Xia Zhang
title	TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
title_short	TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
title_full	TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
title_fullStr	TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
title_full_unstemmed	TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
title_sort	trim27 mediates stat3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-08-01
description	Aberrant and persistent activation of the transcription factor STAT3 has been found in various types of cancers. Here the authors identify TRIM27 as a positive regulator of IL-6-induced STAT3 activation through the formation of JAK1-STAT3 complex, thus impacting inflammation-induced colon cancer development.
url	https://doi.org/10.1038/s41467-018-05796-z
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TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis

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