Results of an open multicenter study of theefficiency of one-week antihelicobacter therapy using omeprazole, clarithromycin, and amoxycillin in patients withduodenal peptic ulcer

• Main Authors: V A Isakov, I V Maev, V I Simanenkov, A V Kononov, R A Abdulkhakov, N V Zakharova, M A Livzan, I K Predvechnaya
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2003-11-01
• Series: Терапевтический архив
• Subjects: duodenal peptic ulcer; exacerbation; treatment; omeprazole; clarithromycin; amoxycillin
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/29715

Aim. To study the efficiency of one-week antihelicobacter therapy using omeprazole, clarithromycin, and amoxycillin in patients with duodenal peptic ulcer during its recurrence. Materials and methods. 105 patients with recurrent peptic ulcer and a not less than 0.5-cm ulcer in the duodenal bulb was given triple therapy: omeprazole, 20 mg twice daily, amoxycillin, 1000 mg twice sidaily, and clarithromycin, 500 mg twice daily for 7 days. Then the patients were allowed to take antacids if they were required to abolish the symptoms of recurrent peptic ulcer. H. pylori was detected in the mucosal biopsy specimens taken from the anthral part and body of the stomach at gastroduodenoscopy, by using the rapid urease test and histology. Gastroduodenoscopy was performed before and 4-6 weeks after the triple therapy. Results. The major symptoms of recurrent peptic ulcer were eliminated in 90% of the patients by the end of a course of therapy, i.e. on its day 7. By the control time, the rate of ulcer cicatrization was 99.05% (104/105). The coincidence of results of the two tests has indicated that H. pylori eradication was 81.9% (86/105) 4-6 weeks after termination of treatment. Adverse reactions during therapy were observed in 20% of the patients; however, treatment had to be discontinued only in 2.9% of the patients. Conclusion. One-week triple therapy using omeprazole, clarithromycin, and amoxycillin is highly effective in treating duodenal peptic ulcer during its recurrence.