Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
Alterations in the MAPK pathway are common in cancers, yet mutations are rarely found in patients. Here the authors find genomic amplifications of the PPP1CA gene in advanced and metastatic prostate cancer and identify a role for this phosphatase in the positive regulation of ERK signalling.
Bibliographic Details
| Main Authors: |
Ming Chen,
Lixin Wan,
Jiangwen Zhang,
Jinfang Zhang,
Lourdes Mendez,
John G. Clohessy,
Kelsey Berry,
Joshua Victor,
Qing Yin,
Yuan Zhu,
Wenyi Wei,
Pier Paolo Pandolfi |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-02272-y
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