Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism

Alterations in the MAPK pathway are common in cancers, yet mutations are rarely found in patients. Here the authors find genomic amplifications of the PPP1CA gene in advanced and metastatic prostate cancer and identify a role for this phosphatase in the positive regulation of ERK signalling.

Bibliographic Details
Main Authors:	Ming Chen, Lixin Wan, Jiangwen Zhang, Jinfang Zhang, Lourdes Mendez, John G. Clohessy, Kelsey Berry, Joshua Victor, Qing Yin, Yuan Zhu, Wenyi Wei, Pier Paolo Pandolfi
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02272-y

id	doaj-3c35271d6beb405c951ac4056c1c2de6
record_format	Article
spelling	doaj-3c35271d6beb405c951ac4056c1c2de62021-05-11T09:21:19ZengNature Publishing GroupNature Communications2041-17232018-01-01911910.1038/s41467-017-02272-yDeregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanismMing Chen0Lixin Wan1Jiangwen Zhang2Jinfang Zhang3Lourdes Mendez4John G. Clohessy5Kelsey Berry6Joshua Victor7Qing Yin8Yuan Zhu9Wenyi Wei10Pier Paolo Pandolfi11Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolSchool of Biological Sciences, The University of Hong KongDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research InstituteDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolCancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolAlterations in the MAPK pathway are common in cancers, yet mutations are rarely found in patients. Here the authors find genomic amplifications of the PPP1CA gene in advanced and metastatic prostate cancer and identify a role for this phosphatase in the positive regulation of ERK signalling.https://doi.org/10.1038/s41467-017-02272-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ming Chen Lixin Wan Jiangwen Zhang Jinfang Zhang Lourdes Mendez John G. Clohessy Kelsey Berry Joshua Victor Qing Yin Yuan Zhu Wenyi Wei Pier Paolo Pandolfi
spellingShingle	Ming Chen Lixin Wan Jiangwen Zhang Jinfang Zhang Lourdes Mendez John G. Clohessy Kelsey Berry Joshua Victor Qing Yin Yuan Zhu Wenyi Wei Pier Paolo Pandolfi Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism Nature Communications
author_facet	Ming Chen Lixin Wan Jiangwen Zhang Jinfang Zhang Lourdes Mendez John G. Clohessy Kelsey Berry Joshua Victor Qing Yin Yuan Zhu Wenyi Wei Pier Paolo Pandolfi
author_sort	Ming Chen
title	Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
title_short	Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
title_full	Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
title_fullStr	Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
title_full_unstemmed	Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism
title_sort	deregulated pp1α phosphatase activity towards mapk activation is antagonized by a tumor suppressive failsafe mechanism
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	Alterations in the MAPK pathway are common in cancers, yet mutations are rarely found in patients. Here the authors find genomic amplifications of the PPP1CA gene in advanced and metastatic prostate cancer and identify a role for this phosphatase in the positive regulation of ERK signalling.
url	https://doi.org/10.1038/s41467-017-02272-y
work_keys_str_mv	AT mingchen deregulatedpp1aphosphataseactivitytowardsmapkactivationisantagonizedbyatumorsuppressivefailsafemechanism AT lixinwan deregulatedpp1aphosphataseactivitytowardsmapkactivationisantagonizedbyatumorsuppressivefailsafemechanism AT jiangwenzhang deregulatedpp1aphosphataseactivitytowardsmapkactivationisantagonizedbyatumorsuppressivefailsafemechanism AT jinfangzhang deregulatedpp1aphosphataseactivitytowardsmapkactivationisantagonizedbyatumorsuppressivefailsafemechanism AT lourdesmendez deregulatedpp1aphosphataseactivitytowardsmapkactivationisantagonizedbyatumorsuppressivefailsafemechanism AT johngclohessy deregulatedpp1aphosphataseactivitytowardsmapkactivationisantagonizedbyatumorsuppressivefailsafemechanism AT kelseyberry deregulatedpp1aphosphataseactivitytowardsmapkactivationisantagonizedbyatumorsuppressivefailsafemechanism AT joshuavictor deregulatedpp1aphosphataseactivitytowardsmapkactivationisantagonizedbyatumorsuppressivefailsafemechanism AT qingyin deregulatedpp1aphosphataseactivitytowardsmapkactivationisantagonizedbyatumorsuppressivefailsafemechanism AT yuanzhu deregulatedpp1aphosphataseactivitytowardsmapkactivationisantagonizedbyatumorsuppressivefailsafemechanism AT wenyiwei deregulatedpp1aphosphataseactivitytowardsmapkactivationisantagonizedbyatumorsuppressivefailsafemechanism AT pierpaolopandolfi deregulatedpp1aphosphataseactivitytowardsmapkactivationisantagonizedbyatumorsuppressivefailsafemechanism
_version_	1721449971434127360

Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism

Similar Items