Oxygen Tension Regulates Lysosomal Activation and Receptor Tyrosine Kinase Degradation
Oxygen sensing is crucial for adaptation to variable habitats and physiological conditions. Low oxygen tension, or hypoxia, is a common feature of solid tumors, and hypoxic tumors are often more aggressive and resistant to therapy. Here we show that, in cultured mammalian cells, hypoxia suppressed l...
Main Authors: | Jaewoo Hong, Todd R. Wuest, Yongfen Min, P. Charles Lin |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-10-01
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Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/11/11/1653 |
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