Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation.

Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation.

We propose a mesh-free and discrete (particle-based) multi-physics approach for modelling the hydrodynamics in flexible biological valves. In the first part of this study, the method is successfully validated against both traditional modelling techniques and experimental data. In the second part, it...

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Main Authors: Mostapha Ariane, Mohamed Hatem Allouche, Marco Bussone, Fausto Giacosa, Frédéric Bernard, Mostafa Barigou, Alessio Alexiadis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5383103?pdf=render
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spelling doaj-3c49524e44ce435d978ea5ced8b741922020-11-25T02:48:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01124e017479510.1371/journal.pone.0174795Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation.Mostapha ArianeMohamed Hatem AlloucheMarco BussoneFausto GiacosaFrédéric BernardMostafa BarigouAlessio AlexiadisWe propose a mesh-free and discrete (particle-based) multi-physics approach for modelling the hydrodynamics in flexible biological valves. In the first part of this study, the method is successfully validated against both traditional modelling techniques and experimental data. In the second part, it is further developed to account for the formation of solid aggregates in the flow and at the membrane surface. Simulations of various types of aggregates highlight the main benefits of discrete multi-physics and indicate the potential of this approach for coupling the hydrodynamics with phenomena such as clotting and calcification in biological valves.http://europepmc.org/articles/PMC5383103?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Mostapha Ariane
Mohamed Hatem Allouche
Marco Bussone
Fausto Giacosa
Frédéric Bernard
Mostafa Barigou
Alessio Alexiadis
spellingShingle Mostapha Ariane
Mohamed Hatem Allouche
Marco Bussone
Fausto Giacosa
Frédéric Bernard
Mostafa Barigou
Alessio Alexiadis
Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation.
PLoS ONE
author_facet Mostapha Ariane
Mohamed Hatem Allouche
Marco Bussone
Fausto Giacosa
Frédéric Bernard
Mostafa Barigou
Alessio Alexiadis
author_sort Mostapha Ariane
title Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation.
title_short Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation.
title_full Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation.
title_fullStr Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation.
title_full_unstemmed Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation.
title_sort discrete multi-physics: a mesh-free model of blood flow in flexible biological valve including solid aggregate formation.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2017-01-01
description We propose a mesh-free and discrete (particle-based) multi-physics approach for modelling the hydrodynamics in flexible biological valves. In the first part of this study, the method is successfully validated against both traditional modelling techniques and experimental data. In the second part, it is further developed to account for the formation of solid aggregates in the flow and at the membrane surface. Simulations of various types of aggregates highlight the main benefits of discrete multi-physics and indicate the potential of this approach for coupling the hydrodynamics with phenomena such as clotting and calcification in biological valves.
url http://europepmc.org/articles/PMC5383103?pdf=render
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AT mohamedhatemallouche discretemultiphysicsameshfreemodelofbloodflowinflexiblebiologicalvalveincludingsolidaggregateformation
AT marcobussone discretemultiphysicsameshfreemodelofbloodflowinflexiblebiologicalvalveincludingsolidaggregateformation
AT faustogiacosa discretemultiphysicsameshfreemodelofbloodflowinflexiblebiologicalvalveincludingsolidaggregateformation
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AT alessioalexiadis discretemultiphysicsameshfreemodelofbloodflowinflexiblebiologicalvalveincludingsolidaggregateformation
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