Hyper IgE Syndrome and Renal Cell Carcinoma

Hyper IgE Syndrome and Renal Cell Carcinoma

Hyper IgE Syndrome (HIES) is an immunodeficiency disorder characterized by increased serum levels of IgE, eczema, and recurrent cutaneous and pulmonary infections. In this report, we present, to our knowledge, the first documented case of renal cell carcinoma (RCC) found in a patient with HIES. The...

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Main Authors: Neel H. Patel, Mark Ferretti, John L. Phillips
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Case Reports in Urology
Online Access:http://dx.doi.org/10.1155/2017/7083451
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spelling doaj-3c4e99ba194149b1a13e0132533bcf522020-11-24T23:17:52ZengHindawi LimitedCase Reports in Urology2090-696X2090-69782017-01-01201710.1155/2017/70834517083451Hyper IgE Syndrome and Renal Cell CarcinomaNeel H. Patel0Mark Ferretti1John L. Phillips2Department of Urology, New York Medical College, Valhalla, NY, USADepartment of Urology, New York Medical College, Valhalla, NY, USADepartment of Urology, New York Medical College, Valhalla, NY, USAHyper IgE Syndrome (HIES) is an immunodeficiency disorder characterized by increased serum levels of IgE, eczema, and recurrent cutaneous and pulmonary infections. In this report, we present, to our knowledge, the first documented case of renal cell carcinoma (RCC) found in a patient with HIES. The patient received infectious disease clearance prior to obtaining a partial nephrectomy which revealed clear cell histology. Both HIES and RCC have an immunological basis for their pathophysiology and may involve common pathways. Further studies may provide insight into any possible link and clinicians should be mindful of immunocompromised patients who present with risk factors for genitourinary malignancy.http://dx.doi.org/10.1155/2017/7083451
collection DOAJ
language English
format Article
sources DOAJ
author Neel H. Patel
Mark Ferretti
John L. Phillips
spellingShingle Neel H. Patel
Mark Ferretti
John L. Phillips
Hyper IgE Syndrome and Renal Cell Carcinoma
Case Reports in Urology
author_facet Neel H. Patel
Mark Ferretti
John L. Phillips
author_sort Neel H. Patel
title Hyper IgE Syndrome and Renal Cell Carcinoma
title_short Hyper IgE Syndrome and Renal Cell Carcinoma
title_full Hyper IgE Syndrome and Renal Cell Carcinoma
title_fullStr Hyper IgE Syndrome and Renal Cell Carcinoma
title_full_unstemmed Hyper IgE Syndrome and Renal Cell Carcinoma
title_sort hyper ige syndrome and renal cell carcinoma
publisher Hindawi Limited
series Case Reports in Urology
issn 2090-696X
2090-6978
publishDate 2017-01-01
description Hyper IgE Syndrome (HIES) is an immunodeficiency disorder characterized by increased serum levels of IgE, eczema, and recurrent cutaneous and pulmonary infections. In this report, we present, to our knowledge, the first documented case of renal cell carcinoma (RCC) found in a patient with HIES. The patient received infectious disease clearance prior to obtaining a partial nephrectomy which revealed clear cell histology. Both HIES and RCC have an immunological basis for their pathophysiology and may involve common pathways. Further studies may provide insight into any possible link and clinicians should be mindful of immunocompromised patients who present with risk factors for genitourinary malignancy.
url http://dx.doi.org/10.1155/2017/7083451
work_keys_str_mv AT neelhpatel hyperigesyndromeandrenalcellcarcinoma
AT markferretti hyperigesyndromeandrenalcellcarcinoma
AT johnlphillips hyperigesyndromeandrenalcellcarcinoma
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