Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario
The mechanisms of acute respiratory failure other than inflammation and complicating the SARS-CoV-2 infection are still far from being fully understood, thus challenging the management of COVID-19 patients in the critical care setting. In this unforeseen scenario, the role of an individual’s excessi...
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doaj-3c51de26000c49f4baedbabd1ff4c7a02021-03-03T00:02:52ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-011097597510.3390/jcm10050975Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New ScenarioRoberto Tonelli0Alessandro Marchioni1Luca Tabbì2Riccardo Fantini3Stefano Busani4Ivana Castaniere5Dario Andrisani6Filippo Gozzi7Giulia Bruzzi8Linda Manicardi9Jacopo Demurtas10Alessandro Andreani11Gaia Francesca Cappiello12Anna Valeria Samarelli13Enrico Clini14University Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, ItalyUniversity Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, ItalyUniversity Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, ItalyUniversity Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, ItalyIntensive Care Unit, University Hospital of Modena and Reggio Emilia, 41124 Modena, ItalyUniversity Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, ItalyUniversity Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, ItalyUniversity Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, ItalyUniversity Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, ItalyUniversity Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, ItalyClinical and Experimental Medicine PhD Program, University of Modena Reggio Emilia, 41124 Modena, ItalyUniversity Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, ItalyUniversity Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, ItalyUniversity Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, ItalyUniversity Hospital of Modena, Respiratory Diseases Unit, Department of Medical and Surgical Sciences, University of Modena Reggio Emilia, 41124 Modena, ItalyThe mechanisms of acute respiratory failure other than inflammation and complicating the SARS-CoV-2 infection are still far from being fully understood, thus challenging the management of COVID-19 patients in the critical care setting. In this unforeseen scenario, the role of an individual’s excessive spontaneous breathing may acquire critical importance, being one potential and important driver of lung injury and disease progression. The consequences of this acute lung damage may impair lung structure, forecasting the model of a fragile respiratory system. This perspective article aims to analyze the progression of injured lung phenotypes across the SARS-CoV-2 induced respiratory failure, pointing out the role of spontaneous breathing and also tackling the specific respiratory/ventilatory strategy required by the fragile lung type.https://www.mdpi.com/2077-0383/10/5/975SARS-CoV-2COVID-19mechanical ventilationspontaneous breathingacute respiratory distress syndromeacute respiratory failure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Roberto Tonelli Alessandro Marchioni Luca Tabbì Riccardo Fantini Stefano Busani Ivana Castaniere Dario Andrisani Filippo Gozzi Giulia Bruzzi Linda Manicardi Jacopo Demurtas Alessandro Andreani Gaia Francesca Cappiello Anna Valeria Samarelli Enrico Clini |
spellingShingle |
Roberto Tonelli Alessandro Marchioni Luca Tabbì Riccardo Fantini Stefano Busani Ivana Castaniere Dario Andrisani Filippo Gozzi Giulia Bruzzi Linda Manicardi Jacopo Demurtas Alessandro Andreani Gaia Francesca Cappiello Anna Valeria Samarelli Enrico Clini Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario Journal of Clinical Medicine SARS-CoV-2 COVID-19 mechanical ventilation spontaneous breathing acute respiratory distress syndrome acute respiratory failure |
author_facet |
Roberto Tonelli Alessandro Marchioni Luca Tabbì Riccardo Fantini Stefano Busani Ivana Castaniere Dario Andrisani Filippo Gozzi Giulia Bruzzi Linda Manicardi Jacopo Demurtas Alessandro Andreani Gaia Francesca Cappiello Anna Valeria Samarelli Enrico Clini |
author_sort |
Roberto Tonelli |
title |
Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario |
title_short |
Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario |
title_full |
Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario |
title_fullStr |
Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario |
title_full_unstemmed |
Spontaneous Breathing and Evolving Phenotypes of Lung Damage in Patients with COVID-19: Review of Current Evidence and Forecast of a New Scenario |
title_sort |
spontaneous breathing and evolving phenotypes of lung damage in patients with covid-19: review of current evidence and forecast of a new scenario |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-03-01 |
description |
The mechanisms of acute respiratory failure other than inflammation and complicating the SARS-CoV-2 infection are still far from being fully understood, thus challenging the management of COVID-19 patients in the critical care setting. In this unforeseen scenario, the role of an individual’s excessive spontaneous breathing may acquire critical importance, being one potential and important driver of lung injury and disease progression. The consequences of this acute lung damage may impair lung structure, forecasting the model of a fragile respiratory system. This perspective article aims to analyze the progression of injured lung phenotypes across the SARS-CoV-2 induced respiratory failure, pointing out the role of spontaneous breathing and also tackling the specific respiratory/ventilatory strategy required by the fragile lung type. |
topic |
SARS-CoV-2 COVID-19 mechanical ventilation spontaneous breathing acute respiratory distress syndrome acute respiratory failure |
url |
https://www.mdpi.com/2077-0383/10/5/975 |
work_keys_str_mv |
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