Effect of primary packaging on microbiological status of oral solid dosage form

Effect of primary packaging on microbiological status of oral solid dosage form

The emergence of microbial contaminants in non-sterile drugs caused not only the degradation of many products, but also proved to be a potential risk to consumer health. The aim of this study was to test microbial load of non sterile solid pharmaceutical product and investigate the effects of differ...

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Bibliographic Details
Main Authors: Meenal Khana, U. V. S Teotia, Yogendra Siingh
Format: Article
Language:English
Published: Creative Pharma Assent 2018-03-01
Series:Journal of Applied Pharmaceutical Research
Subjects:
microbiological quality
alu-alu
blister
total aerobic microbial counts (tamc)total yeast and mold counts (tymc)
Online Access:https://japtronline.com/index.php/joapr/article/view/96
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spelling doaj-3c5a12b65a40493eb091f7c29d4d3c4f2021-09-11T15:16:59ZengCreative Pharma AssentJournal of Applied Pharmaceutical Research2348-03352018-03-0161010610.18231/2348-0335.2018.000196Effect of primary packaging on microbiological status of oral solid dosage formMeenal Khana0U. V. S Teotia1Yogendra Siingh2Shri venkateshwara university, Gajraula Dist. J.P Nagar, Uttar PradeshShri venkateshwara university, Gajraula Dist. J.P Nagar, Uttar PradeshZydus Cadilla Ltd, Baddi, Himachal PradeshThe emergence of microbial contaminants in non-sterile drugs caused not only the degradation of many products, but also proved to be a potential risk to consumer health. The aim of this study was to test microbial load of non sterile solid pharmaceutical product and investigate the effects of different packaging system on microbial status of pharmaceutical product. A total of 18 sample of solid dosage form packaged in different packaging were procured from market. All samples have been tested for the presence of specific microorganisms, Total aerobic microbial counts (TAMC) and Total yeast and mold counts (TYMC) using compendial procedures. Out of 18 sample 72.22 % (n=13) had shown microbial growth and only 16 % (n=3) of samples were non-compliant. Sample containing herbal ingredients, were the most heavily contaminated, showing a bacterial load > 104 CFU/g. The result showed that all the tested samples were free from E. coli. There was no significant difference (p>0.05) in microbial load of product packaged in different primary packaginghttps://japtronline.com/index.php/joapr/article/view/96microbiological qualityalu-alublistertotal aerobic microbial counts (tamc)total yeast and mold counts (tymc)
collection DOAJ
language English
format Article
sources DOAJ
author Meenal Khana
U. V. S Teotia
Yogendra Siingh
spellingShingle Meenal Khana
U. V. S Teotia
Yogendra Siingh
Effect of primary packaging on microbiological status of oral solid dosage form
Journal of Applied Pharmaceutical Research
microbiological quality
alu-alu
blister
total aerobic microbial counts (tamc)total yeast and mold counts (tymc)
author_facet Meenal Khana
U. V. S Teotia
Yogendra Siingh
author_sort Meenal Khana
title Effect of primary packaging on microbiological status of oral solid dosage form
title_short Effect of primary packaging on microbiological status of oral solid dosage form
title_full Effect of primary packaging on microbiological status of oral solid dosage form
title_fullStr Effect of primary packaging on microbiological status of oral solid dosage form
title_full_unstemmed Effect of primary packaging on microbiological status of oral solid dosage form
title_sort effect of primary packaging on microbiological status of oral solid dosage form
publisher Creative Pharma Assent
series Journal of Applied Pharmaceutical Research
issn 2348-0335
publishDate 2018-03-01
description The emergence of microbial contaminants in non-sterile drugs caused not only the degradation of many products, but also proved to be a potential risk to consumer health. The aim of this study was to test microbial load of non sterile solid pharmaceutical product and investigate the effects of different packaging system on microbial status of pharmaceutical product. A total of 18 sample of solid dosage form packaged in different packaging were procured from market. All samples have been tested for the presence of specific microorganisms, Total aerobic microbial counts (TAMC) and Total yeast and mold counts (TYMC) using compendial procedures. Out of 18 sample 72.22 % (n=13) had shown microbial growth and only 16 % (n=3) of samples were non-compliant. Sample containing herbal ingredients, were the most heavily contaminated, showing a bacterial load > 104 CFU/g. The result showed that all the tested samples were free from E. coli. There was no significant difference (p>0.05) in microbial load of product packaged in different primary packaging
topic microbiological quality
alu-alu
blister
total aerobic microbial counts (tamc)total yeast and mold counts (tymc)
url https://japtronline.com/index.php/joapr/article/view/96
work_keys_str_mv AT meenalkhana effectofprimarypackagingonmicrobiologicalstatusoforalsoliddosageform
AT uvsteotia effectofprimarypackagingonmicrobiologicalstatusoforalsoliddosageform
AT yogendrasiingh effectofprimarypackagingonmicrobiologicalstatusoforalsoliddosageform
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