TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2[S]
Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes. This study aims to identify repressor elements in the human SOAT2 promoter and evaluate their in vivo relevance. We identified TG-interacting factor 1 (Tgif1) to function as an important repr...
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Elsevier
2014-04-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520376598 |
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doaj-3c5d58da3a6842ff840aba6230e5c72d2021-04-28T06:02:21ZengElsevierJournal of Lipid Research0022-22752014-04-01554709717TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2[S]Camilla Pramfalk0Tiffany A. Melhuish1David Wotton2Zhao-Yan Jiang3Mats Eriksson4Paolo Parini5Division of Clinical Chemistry, Department of Laboratory Medicine, and Centre for Nutrition and Toxicology, NOVUM, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden; Molecular Nutrition Unit, Department of Biosciences and Nutrition, Centre for Nutrition and Toxicology, NOVUM, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, SwedenDepartment of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, VADepartment of Biochemistry and Molecular Genetics and Center for Cell Signaling, University of Virginia, Charlottesville, VADepartment of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; andMolecular Nutrition Unit, Department of Biosciences and Nutrition, Centre for Nutrition and Toxicology, NOVUM, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden; Metabolism Unit, Department of Endocrinology, Metabolism and Diabetes, and Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, SwedenTo whom correspondence should be addressed; Division of Clinical Chemistry, Department of Laboratory Medicine, and Centre for Nutrition and Toxicology, NOVUM, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden; Molecular Nutrition Unit, Department of Biosciences and Nutrition, Centre for Nutrition and Toxicology, NOVUM, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden; To whom correspondence should be addressedAcat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes. This study aims to identify repressor elements in the human SOAT2 promoter and evaluate their in vivo relevance. We identified TG-interacting factor 1 (Tgif1) to function as an important repressor of SOAT2. Tgif1 could also block the induction of the SOAT2 promoter activity by hepatocyte nuclear factor 1α and 4α. Women have ∼30% higher hepatic TGIF1 mRNA compared with men. Depletion of Tgif1 in mice increased the hepatic Soat2 expression and resulted in higher hepatic lipid accumulation and plasma cholesterol levels. Tgif1 is a new player in human cholesterol metabolism.http://www.sciencedirect.com/science/article/pii/S0022227520376598hepatocyte nuclear factor 1α and 4αliverhumantriglyceride |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Camilla Pramfalk Tiffany A. Melhuish David Wotton Zhao-Yan Jiang Mats Eriksson Paolo Parini |
| spellingShingle |
Camilla Pramfalk Tiffany A. Melhuish David Wotton Zhao-Yan Jiang Mats Eriksson Paolo Parini TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2[S] Journal of Lipid Research hepatocyte nuclear factor 1α and 4α liver human triglyceride |
| author_facet |
Camilla Pramfalk Tiffany A. Melhuish David Wotton Zhao-Yan Jiang Mats Eriksson Paolo Parini |
| author_sort |
Camilla Pramfalk |
| title |
TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2[S] |
| title_short |
TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2[S] |
| title_full |
TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2[S] |
| title_fullStr |
TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2[S] |
| title_full_unstemmed |
TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2[S] |
| title_sort |
tg-interacting factor 1 acts as a transcriptional repressor of sterol o-acyltransferase 2[s] |
| publisher |
Elsevier |
| series |
Journal of Lipid Research |
| issn |
0022-2275 |
| publishDate |
2014-04-01 |
| description |
Acat2 [gene name: sterol O-acyltransferase 2 (SOAT2)] esterifies cholesterol in enterocytes and hepatocytes. This study aims to identify repressor elements in the human SOAT2 promoter and evaluate their in vivo relevance. We identified TG-interacting factor 1 (Tgif1) to function as an important repressor of SOAT2. Tgif1 could also block the induction of the SOAT2 promoter activity by hepatocyte nuclear factor 1α and 4α. Women have ∼30% higher hepatic TGIF1 mRNA compared with men. Depletion of Tgif1 in mice increased the hepatic Soat2 expression and resulted in higher hepatic lipid accumulation and plasma cholesterol levels. Tgif1 is a new player in human cholesterol metabolism. |
| topic |
hepatocyte nuclear factor 1α and 4α liver human triglyceride |
| url |
http://www.sciencedirect.com/science/article/pii/S0022227520376598 |
| work_keys_str_mv |
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