RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 mice

Growing evidence demonstrates the epigenetic modulation as a key event in Alzheimer's disease (AD) pathology. Furthermore, recent data suggests that the epigenetic regulation by the methyltransferase G9a is a crucial mechanism involved in learning and memory formation. Taking this into account,...

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Main Authors:	Shrikant Pawar, Aina Bellver-Sanchis, Christian Griñán-Ferré
Format:	Article
Language:	English
Published:	Elsevier 2021-06-01
Series:	Data in Brief
Subjects:	Epigenetics Alzheimer's disease RNA seq SAMP8 SAMR1 UNC0642
Online Access:	http://www.sciencedirect.com/science/article/pii/S235234092100398X

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spelling	doaj-3c64ca1c3b324e4aaea0bb541f2cf9102021-06-27T04:38:24ZengElsevierData in Brief2352-34092021-06-0136107114RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 miceShrikant Pawar0Aina Bellver-Sanchis1Christian Griñán-Ferré2Department of Genetics, Yale University, New Haven, CT, USADepartment of Pharmacology and Therapeutic Chemistry, Institut de Neurociències-Universitat de Barcelona, Avda. Joan XXIII, 27, Barcelona 08028, SpainDepartment of Pharmacology and Therapeutic Chemistry, Institut de Neurociències-Universitat de Barcelona, Avda. Joan XXIII, 27, Barcelona 08028, Spain; Corresponding author.Growing evidence demonstrates the epigenetic modulation as a key event in Alzheimer's disease (AD) pathology. Furthermore, recent data suggests that the epigenetic regulation by the methyltransferase G9a is a crucial mechanism involved in learning and memory formation. Taking this into account, we hereby provide genomics data from pharmacological intervention with UNC0642, a potent and selective G9a/GLP in SAMP8 mice, a model of Alzheimer's disease (AD). We have generated novel RNA-seq and miRNA-seq data for three groups, healthy SAMR1, SAMP8 control and SAMP8 treated with UNC0642 (5 mg/Kg). Thus, the new data can be used to find miRNA regulation, and the mRNA's modified in AD under G9a/GLP inhibition.http://www.sciencedirect.com/science/article/pii/S235234092100398XEpigeneticsAlzheimer's diseaseRNA seqSAMP8SAMR1UNC0642
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shrikant Pawar Aina Bellver-Sanchis Christian Griñán-Ferré
spellingShingle	Shrikant Pawar Aina Bellver-Sanchis Christian Griñán-Ferré RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 mice Data in Brief Epigenetics Alzheimer's disease RNA seq SAMP8 SAMR1 UNC0642
author_facet	Shrikant Pawar Aina Bellver-Sanchis Christian Griñán-Ferré
author_sort	Shrikant Pawar
title	RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 mice
title_short	RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 mice
title_full	RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 mice
title_fullStr	RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 mice
title_full_unstemmed	RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 mice
title_sort	rna-seq and mirna-seq data from pharmacological inhibition of the g9a/glp histone methyltransferase complex with unc0642 in samp8 mice
publisher	Elsevier
series	Data in Brief
issn	2352-3409
publishDate	2021-06-01
description	Growing evidence demonstrates the epigenetic modulation as a key event in Alzheimer's disease (AD) pathology. Furthermore, recent data suggests that the epigenetic regulation by the methyltransferase G9a is a crucial mechanism involved in learning and memory formation. Taking this into account, we hereby provide genomics data from pharmacological intervention with UNC0642, a potent and selective G9a/GLP in SAMP8 mice, a model of Alzheimer's disease (AD). We have generated novel RNA-seq and miRNA-seq data for three groups, healthy SAMR1, SAMP8 control and SAMP8 treated with UNC0642 (5 mg/Kg). Thus, the new data can be used to find miRNA regulation, and the mRNA's modified in AD under G9a/GLP inhibition.
topic	Epigenetics Alzheimer's disease RNA seq SAMP8 SAMR1 UNC0642
url	http://www.sciencedirect.com/science/article/pii/S235234092100398X
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RNA-seq and miRNA-seq data from pharmacological inhibition of the G9a/GLP histone methyltransferase complex with UNC0642 in SAMP8 mice

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