Biologic Agents for Periodontal Regeneration and Implant Site Development
The advancement of molecular mediators or biologic agents has increased tremendously during the last decade in periodontology and dental implantology. Implant site development and reconstruction of the lost periodontium represent main fields in which these molecular mediators have been employed and...
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Online Access: | http://dx.doi.org/10.1155/2015/957518 |
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doaj-3c66dbe3c2fa4544b8cb74b17bc15a122020-11-25T01:36:43ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/957518957518Biologic Agents for Periodontal Regeneration and Implant Site DevelopmentFernando Suárez-López del Amo0Alberto Monje1Miguel Padial-Molina2ZhiHui Tang3Hom-Lay Wang4Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USADepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USADepartment of Oral Surgery and Implant Dentistry, University of Granada, Granada, Spain2nd Clinical Division, Peking University School of Stomatology, Beijing, ChinaDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USAThe advancement of molecular mediators or biologic agents has increased tremendously during the last decade in periodontology and dental implantology. Implant site development and reconstruction of the lost periodontium represent main fields in which these molecular mediators have been employed and investigated. Different growth factors trigger different reactions in the tissues of the periodontium at various cellular levels. Proliferation, migration, and differentiation constitute the main target areas of these molecular mediators. It was the purpose of this comprehensive review to describe the origin and rationale, evidence, and the most current understanding of the following biologic agents: Recombinant Human Platelet-Derived Growth Factor-BB (rhPDGF-BB), Enamel Matrix Derivate (EMD), Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF), Recombinant Human Fibroblast Growth Factor-2 (rhFGF-2), Bone Morphogenic Proteins (BMPs, BMP-2 and BMP-7), Teriparatide PTH, and Growth Differential Factor-5 (GDF-5).http://dx.doi.org/10.1155/2015/957518 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fernando Suárez-López del Amo Alberto Monje Miguel Padial-Molina ZhiHui Tang Hom-Lay Wang |
spellingShingle |
Fernando Suárez-López del Amo Alberto Monje Miguel Padial-Molina ZhiHui Tang Hom-Lay Wang Biologic Agents for Periodontal Regeneration and Implant Site Development BioMed Research International |
author_facet |
Fernando Suárez-López del Amo Alberto Monje Miguel Padial-Molina ZhiHui Tang Hom-Lay Wang |
author_sort |
Fernando Suárez-López del Amo |
title |
Biologic Agents for Periodontal Regeneration and Implant Site Development |
title_short |
Biologic Agents for Periodontal Regeneration and Implant Site Development |
title_full |
Biologic Agents for Periodontal Regeneration and Implant Site Development |
title_fullStr |
Biologic Agents for Periodontal Regeneration and Implant Site Development |
title_full_unstemmed |
Biologic Agents for Periodontal Regeneration and Implant Site Development |
title_sort |
biologic agents for periodontal regeneration and implant site development |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
The advancement of molecular mediators or biologic agents has increased tremendously during the last decade in periodontology and dental implantology. Implant site development and reconstruction of the lost periodontium represent main fields in which these molecular mediators have been employed and investigated. Different growth factors trigger different reactions in the tissues of the periodontium at various cellular levels. Proliferation, migration, and differentiation constitute the main target areas of these molecular mediators. It was the purpose of this comprehensive review to describe the origin and rationale, evidence, and the most current understanding of the following biologic agents: Recombinant Human Platelet-Derived Growth Factor-BB (rhPDGF-BB), Enamel Matrix Derivate (EMD), Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF), Recombinant Human Fibroblast Growth Factor-2 (rhFGF-2), Bone Morphogenic Proteins (BMPs, BMP-2 and BMP-7), Teriparatide PTH, and Growth Differential Factor-5 (GDF-5). |
url |
http://dx.doi.org/10.1155/2015/957518 |
work_keys_str_mv |
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