Structural Comparisons of Cefotaximase (CTX-M-ase) Sub Family 1

Structural Comparisons of Cefotaximase (CTX-M-ase) Sub Family 1

The cefotaximase or CTX-M, family of serine-β-lactamases represents a significant clinical concern due to the ability for these enzymes to confer resistance to a broad array of β-lactam antibiotics an inhibitors. This behavior lends CTX-M-ases to be classified as extended spectrum β-lactamases (ESBL...

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Bibliographic Details
Main Authors:	Ben A. Shurina, Richard C. Page
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-08-01
Series:	Frontiers in Microbiology
Subjects:	cefotaximase serine-beta-lactamase lactamase CTX diazabicyclooctane boronic acid transition state analog inhibitor
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2021.688509/full

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