Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy

Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy

The human NKCC1 transporter belongs to the cation–chloride cotransporter (CCC) family and has important physiological functions, among them the regulation of chloride homeostasis and neuronal excitability. Here the authors present the 3.46 Å cryo-EM structure of human NKCC1 in a in a partially loade...

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Main Authors: Xiaoyong Yang, Qinzhe Wang, Erhu Cao
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14790-3
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spelling doaj-3c7bbf82d06b49a88e2a0dccd90257902021-05-11T08:36:52ZengNature Publishing GroupNature Communications2041-17232020-02-0111111110.1038/s41467-020-14790-3Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopyXiaoyong Yang0Qinzhe Wang1Erhu Cao2Department of Biochemistry, University of Utah School of MedicineDepartment of Biochemistry, University of Utah School of MedicineDepartment of Biochemistry, University of Utah School of MedicineThe human NKCC1 transporter belongs to the cation–chloride cotransporter (CCC) family and has important physiological functions, among them the regulation of chloride homeostasis and neuronal excitability. Here the authors present the 3.46 Å cryo-EM structure of human NKCC1 in a in a partially loaded, inward-open state and discuss the transport mechanism.https://doi.org/10.1038/s41467-020-14790-3
collection DOAJ
language English
format Article
sources DOAJ
author Xiaoyong Yang
Qinzhe Wang
Erhu Cao
spellingShingle Xiaoyong Yang
Qinzhe Wang
Erhu Cao
Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
Nature Communications
author_facet Xiaoyong Yang
Qinzhe Wang
Erhu Cao
author_sort Xiaoyong Yang
title Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
title_short Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
title_full Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
title_fullStr Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
title_full_unstemmed Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy
title_sort structure of the human cation–chloride cotransporter nkcc1 determined by single-particle electron cryo-microscopy
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-02-01
description The human NKCC1 transporter belongs to the cation–chloride cotransporter (CCC) family and has important physiological functions, among them the regulation of chloride homeostasis and neuronal excitability. Here the authors present the 3.46 Å cryo-EM structure of human NKCC1 in a in a partially loaded, inward-open state and discuss the transport mechanism.
url https://doi.org/10.1038/s41467-020-14790-3
work_keys_str_mv AT xiaoyongyang structureofthehumancationchloridecotransporternkcc1determinedbysingleparticleelectroncryomicroscopy
AT qinzhewang structureofthehumancationchloridecotransporternkcc1determinedbysingleparticleelectroncryomicroscopy
AT erhucao structureofthehumancationchloridecotransporternkcc1determinedbysingleparticleelectroncryomicroscopy
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