Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy

The human NKCC1 transporter belongs to the cation–chloride cotransporter (CCC) family and has important physiological functions, among them the regulation of chloride homeostasis and neuronal excitability. Here the authors present the 3.46 Å cryo-EM structure of human NKCC1 in a in a partially loade...

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Bibliographic Details
Main Authors: Xiaoyong Yang, Qinzhe Wang, Erhu Cao
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14790-3