Staphylococcus aureus Leukocidin LukED and HIV-1 gp120 Target Different Sequence Determinants on CCR5

Staphylococcus aureus Leukocidin LukED and HIV-1 gp120 Target Different Sequence Determinants on CCR5

Leukocidin ED (LukED) is a bicomponent pore-forming toxin produced by Staphylococcus aureus that lyses host cells by targeting the chemokine receptors CC chemokine receptor type 5 (CCR5), CXCR1, CXCR2, and DARC. In addition to its role as a receptor for LukED, CCR5 is the major coreceptor for primar...

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Bibliographic Details
Main Authors:	Kayan Tam, Megan Schultz, Tamara Reyes-Robles, Bénéédicte Vanwalscappel, Joshua Horton, Francis Alonzo, Beili Wu, Nathaniel R. Landau, Victor J. Torres
Format:	Article
Language:	English
Published:	American Society for Microbiology 2016-12-01
Series:	mBio
Online Access:	http://mbio.asm.org/cgi/content/full/7/6/e02024-16

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