Role of TSH on Urinary Calcium Excretion In Post Menopausal Women of South Indian Population
Background: Unforeseen aberrations in the hormonal status during the early postmenopausal period are responsible for several complications including osteoporosis. Thyroid Stimulating Hormone (TSH) receptors are isolated from various tissues including the bone. A low serum TSH level is known to st...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2013-06-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/3056/30%20-%205290_E(C)_PF1(M)_F(H)_PF1(H)_PF1(PUH)_PFA(PUH).pdf |
Summary: | Background: Unforeseen aberrations in the hormonal status
during the early postmenopausal period are responsible for
several complications including osteoporosis. Thyroid Stimulating Hormone (TSH) receptors are isolated from various tissues including the bone. A low serum TSH level is known to
stimulate osteoclastic activity in bone and accelerate bone
resorption. Urinary calcium/creatinine (UCa/Cr) excretion ratio could be an indirect and an early indicator of loss of Bone
Mineral Density (BMD). With this background, this study was
planned to explore the association of serum TSH levels with
the UCa/Cr excretion ratio.
Methods: Forty eight women in the postmenopausal age
group, with their menopausal age not more than seven years
of duration were included in this study. Based on their TSH values, these subjects were divided into two groups A (TSH<0.5
mIU/L) and B (TSH>0.5mIU/L). Urinary calcium, UCa/Cr excretion ratio, serum phosphorous, calcium and calcium phosphorous multiplication products were estimated and compared
between the two groups.
Results: Twenty two (46%) women were biochemically asymptomatic hyperthyroid cases and Twenty six (54%) were euthyroid. This study documents high UCa/Cr in Group A compared
to that of Group B (p<0.05). We also observed significant negative correlation of TSH with UCa/Cr excretion ratio (p=0.041, r
= -0.43).
Conclusion: Low serum TSH levels were associated with increased UCa/Cr excretion ratio in postmenopausal women of
South Indian population. |
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ISSN: | 2249-782X 0973-709X |