Is it possible to identify individuals with mild cognitive impairment and Alzheimer's disease using a 30-minute neuropsychological battery?
evaluation. METHODS: One hundred and thirty-one consecutive referred elderly patients (37 clinical-controls, 41 with amnestic MCI and 53 with possible/probable AD) were diagnosed with a comprehensive (full) neuropsychological battery, MRI and clinical data. All of the results were blindly coded and...
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doaj-3c8990b9ddc546f0a804f1d03209a6b92020-11-25T01:50:31ZengUniversidade de São PauloArchives of Clinical Psychiatry1806-938X2013-01-0140413914310.1590/S0101-60832013000400003S0101-60832013000400003Is it possible to identify individuals with mild cognitive impairment and Alzheimer's disease using a 30-minute neuropsychological battery?Gabriel Coutinho0Ricardo de Oliveira-Souza1Jorge Moll2Fernanda Tovar-Moll3Paulo Mattos4Instituto D'OrInstituto D'OrInstituto D'OrInstituto D'OrInstituto D'Orevaluation. METHODS: One hundred and thirty-one consecutive referred elderly patients (37 clinical-controls, 41 with amnestic MCI and 53 with possible/probable AD) were diagnosed with a comprehensive (full) neuropsychological battery, MRI and clinical data. All of the results were blindly coded and evaluated latter with a subset of the tests to reclassify the subjects as MCI, dementia or clinical-control. Agreement rates between both batteries were calculated. We also used ROC curves to establish the sensitivity and specificity of the brief battery for discriminating (i) clinical-control individuals from a group dementia and MCI patients; (ii) individuals with dementia from individuals without dementia; (iii) clinical-control individuals from a group of MCI. We compared performance of the three groups on all full battery tasks. RESULTS: All neuropsychological tests showed differences between clinical-control and dementia groups. The comparison between MCI and the other groups mainly showed memory differences. Agreement between brief and full batteries was substantial (kappa = 0.805). Analyses with ROC curves showed good sensitivity and specificity to discriminate non-demented (clinical control plus MCI groups) and AD group and also to discriminate clinical-control individuals from individuals with cognitive decline (MCI plus AD group). However, sensitivity and specificity significantly decreased when brief battery was tested to discriminate only normal and MCI diagnosis. DISCUSSION: The use of a brief battery might not be indicated to discriminate MCI and clinical-control individuals, but its use might be adequate to discriminate less specific groups (demented versus non-demented and pathological [dementia and MCI] and non-pathological [clinical-control] groups).http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-60832013000400003&lng=en&tlng=enDoença de Alzheimeravaliação cognitivademênciamemóriacomprometimento cognitivo leve |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gabriel Coutinho Ricardo de Oliveira-Souza Jorge Moll Fernanda Tovar-Moll Paulo Mattos |
spellingShingle |
Gabriel Coutinho Ricardo de Oliveira-Souza Jorge Moll Fernanda Tovar-Moll Paulo Mattos Is it possible to identify individuals with mild cognitive impairment and Alzheimer's disease using a 30-minute neuropsychological battery? Archives of Clinical Psychiatry Doença de Alzheimer avaliação cognitiva demência memória comprometimento cognitivo leve |
author_facet |
Gabriel Coutinho Ricardo de Oliveira-Souza Jorge Moll Fernanda Tovar-Moll Paulo Mattos |
author_sort |
Gabriel Coutinho |
title |
Is it possible to identify individuals with mild cognitive impairment and Alzheimer's disease using a 30-minute neuropsychological battery? |
title_short |
Is it possible to identify individuals with mild cognitive impairment and Alzheimer's disease using a 30-minute neuropsychological battery? |
title_full |
Is it possible to identify individuals with mild cognitive impairment and Alzheimer's disease using a 30-minute neuropsychological battery? |
title_fullStr |
Is it possible to identify individuals with mild cognitive impairment and Alzheimer's disease using a 30-minute neuropsychological battery? |
title_full_unstemmed |
Is it possible to identify individuals with mild cognitive impairment and Alzheimer's disease using a 30-minute neuropsychological battery? |
title_sort |
is it possible to identify individuals with mild cognitive impairment and alzheimer's disease using a 30-minute neuropsychological battery? |
publisher |
Universidade de São Paulo |
series |
Archives of Clinical Psychiatry |
issn |
1806-938X |
publishDate |
2013-01-01 |
description |
evaluation. METHODS: One hundred and thirty-one consecutive referred elderly patients (37 clinical-controls, 41 with amnestic MCI and 53 with possible/probable AD) were diagnosed with a comprehensive (full) neuropsychological battery, MRI and clinical data. All of the results were blindly coded and evaluated latter with a subset of the tests to reclassify the subjects as MCI, dementia or clinical-control. Agreement rates between both batteries were calculated. We also used ROC curves to establish the sensitivity and specificity of the brief battery for discriminating (i) clinical-control individuals from a group dementia and MCI patients; (ii) individuals with dementia from individuals without dementia; (iii) clinical-control individuals from a group of MCI. We compared performance of the three groups on all full battery tasks. RESULTS: All neuropsychological tests showed differences between clinical-control and dementia groups. The comparison between MCI and the other groups mainly showed memory differences. Agreement between brief and full batteries was substantial (kappa = 0.805). Analyses with ROC curves showed good sensitivity and specificity to discriminate non-demented (clinical control plus MCI groups) and AD group and also to discriminate clinical-control individuals from individuals with cognitive decline (MCI plus AD group). However, sensitivity and specificity significantly decreased when brief battery was tested to discriminate only normal and MCI diagnosis. DISCUSSION: The use of a brief battery might not be indicated to discriminate MCI and clinical-control individuals, but its use might be adequate to discriminate less specific groups (demented versus non-demented and pathological [dementia and MCI] and non-pathological [clinical-control] groups). |
topic |
Doença de Alzheimer avaliação cognitiva demência memória comprometimento cognitivo leve |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-60832013000400003&lng=en&tlng=en |
work_keys_str_mv |
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