Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey
Abstract The objective of this analysis was to evaluate the change over time in age at first symptoms, age at diagnosis, and delay in diagnosis using data from the Icatibant Outcome Survey (IOS). Patients with a diagnosis of C1-INH-HAE who were born before the year 1990 and who were diagnosed before...
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doaj-3c9276941ce64034a53aca00eb6720c02021-09-02T05:16:20ZengWileyClinical and Translational Allergy2045-70222018-10-01811510.1186/s13601-018-0229-4Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome SurveyAndrea Zanichelli0Markus Magerl1Hilary J. Longhurst2Werner Aberer3Teresa Caballero4Laurence Bouillet5Anette Bygum6Anete S. Grumach7Jaco Botha8Irmgard Andresen9Marcus Maurer10the IOS Study GroupDepartment of Biomedical and Clinical Sciences Luigi Sacco, University of MilanDepartment of Dermatology and Allergy, Allergie-Centrum-Charité, Charité–Universitätsmedizin BerlinDepartment of Immunology, Barts Health NHS TrustDepartment of Dermatology and Venereology, Medical University of GrazDepartment of Allergy, Hospital La Paz Institute for Health Research (IdiPaz), Biomedical Research Network on Rare Diseases (CIBERER, U754)National Reference Centre for Angioedema, Internal Medicine Department, Grenoble University HospitalDepartment of Dermatology and Allergy Centre, Odense University HospitalFaculdade de Medicina ABCShireShireDepartment of Dermatology and Allergy, Allergie-Centrum-Charité, Charité–Universitätsmedizin BerlinAbstract The objective of this analysis was to evaluate the change over time in age at first symptoms, age at diagnosis, and delay in diagnosis using data from the Icatibant Outcome Survey (IOS). Patients with a diagnosis of C1-INH-HAE who were born before the year 1990 and who were diagnosed before they reached 25 years of age were included in the analysis. Both age at diagnosis and delay in diagnosis of C1-INH-HAE appear to decline with later decade of birth, despite wide variation across the countries assessed, suggesting that improved disease awareness causes increased rates of earlier diagnosis over time. Our findings demonstrate that some patients are still experiencing long delays to diagnosis, indicating an ongoing need for improved disease awareness.http://link.springer.com/article/10.1186/s13601-018-0229-4Hereditary angioedemaHAEC1-INH-HAEDiagnosisDelay in diagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrea Zanichelli Markus Magerl Hilary J. Longhurst Werner Aberer Teresa Caballero Laurence Bouillet Anette Bygum Anete S. Grumach Jaco Botha Irmgard Andresen Marcus Maurer the IOS Study Group |
spellingShingle |
Andrea Zanichelli Markus Magerl Hilary J. Longhurst Werner Aberer Teresa Caballero Laurence Bouillet Anette Bygum Anete S. Grumach Jaco Botha Irmgard Andresen Marcus Maurer the IOS Study Group Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey Clinical and Translational Allergy Hereditary angioedema HAE C1-INH-HAE Diagnosis Delay in diagnosis |
author_facet |
Andrea Zanichelli Markus Magerl Hilary J. Longhurst Werner Aberer Teresa Caballero Laurence Bouillet Anette Bygum Anete S. Grumach Jaco Botha Irmgard Andresen Marcus Maurer the IOS Study Group |
author_sort |
Andrea Zanichelli |
title |
Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey |
title_short |
Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey |
title_full |
Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey |
title_fullStr |
Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey |
title_full_unstemmed |
Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey |
title_sort |
improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the icatibant outcome survey |
publisher |
Wiley |
series |
Clinical and Translational Allergy |
issn |
2045-7022 |
publishDate |
2018-10-01 |
description |
Abstract The objective of this analysis was to evaluate the change over time in age at first symptoms, age at diagnosis, and delay in diagnosis using data from the Icatibant Outcome Survey (IOS). Patients with a diagnosis of C1-INH-HAE who were born before the year 1990 and who were diagnosed before they reached 25 years of age were included in the analysis. Both age at diagnosis and delay in diagnosis of C1-INH-HAE appear to decline with later decade of birth, despite wide variation across the countries assessed, suggesting that improved disease awareness causes increased rates of earlier diagnosis over time. Our findings demonstrate that some patients are still experiencing long delays to diagnosis, indicating an ongoing need for improved disease awareness. |
topic |
Hereditary angioedema HAE C1-INH-HAE Diagnosis Delay in diagnosis |
url |
http://link.springer.com/article/10.1186/s13601-018-0229-4 |
work_keys_str_mv |
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